Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University.
J Exp Psychol Gen. 2018 Dec;147(12):1763-1781. doi: 10.1037/xge0000523.
The catecholamines have long been associated with cognitive control and value-based decision-making. More recently, we proposed that the catecholamines might modulate value-based decision-making about whether or not to engage in cognitive control. We test this hypothesis by assessing effects of a catecholamine challenge in a large sample of young, healthy adults (n = 100) on the avoidance of a cognitively demanding control process: task switching. Prolonging catecholamine transmission by blocking reuptake with methylphenidate altered the avoidance, but not the execution of cognitive control. Crucially, these effects could be isolated by taking into account individual differences in trait impulsivity, so that participants with higher trait impulsivity became more avoidant of cognitive control, despite faster task performance. One implication of these findings is that performance-enhancing effects of methylphenidate may be accompanied by an undermining effect on the willingness to exert cognitive control. Taken together, these findings integrate hitherto segregated literatures on catecholamines' roles in value-based learning/choice and cognitive control. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
儿茶酚胺长期以来一直与认知控制和基于价值的决策相关联。最近，我们提出儿茶酚胺可能调节基于价值的决策，即是否参与认知控制。我们通过在一大群年轻健康成年人（n = 100）中评估儿茶酚胺挑战对认知要求高的控制过程（任务转换）回避的影响来检验这一假设。用哌甲酯阻断再摄取来延长儿茶酚胺传递改变了认知控制的回避，但没有改变其执行。至关重要的是，通过考虑特质冲动的个体差异，可以将这些影响分离出来，因此，特质冲动较高的参与者尽管任务表现更快，但对认知控制的回避程度更高。这些发现的一个含义是，哌甲酯的增强性能的效果可能伴随着对发挥认知控制的意愿的破坏作用。综上所述，这些发现整合了儿茶酚胺在基于价值的学习/选择和认知控制中的作用的迄今为止分离的文献。（心理信息数据库记录（c）2018 APA，保留所有权利）。
