高密度口服狂犬病疫苗诱饵对浣熊（北美浣熊）狂犬病病毒中和抗体反应的影响

EFFECT OF HIGH-DENSITY ORAL RABIES VACCINE BAITING ON RABIES VIRUS NEUTRALIZING ANTIBODY RESPONSE IN RACCOONS ( PROCYON LOTOR).

作者信息

Pedersen Kerri, Gilbert Amy T, Wilhelm Eric S, Nelson Kathleen M, Davis Amy J, Kirby Jordona D, VerCauteren Kurt C, Johnson Shylo R, Chipman Richard B

机构信息

1 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, Colorado 80521, USA.

2 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, Abingdon, Virginia 24210, USA.

出版信息

J Wildl Dis. 2019 Apr;55(2):399-409. doi: 10.7589/2018-05-138. Epub 2018 Dec 3.

DOI:10.7589/2018-05-138

PMID:30507337

Abstract

From 2014 to 2016, we examined the effect of distributing oral rabies vaccine baits at high density (150 baits/km) in an area of Virginia, US that was naïve to oral rabies vaccination prior to the study. We also compared the effect of baiting at high density in a naïve area to baiting at standard density (75 baits/km) in an area that had been baited annually for 12 yr. Our results suggested that rabies virus seroconversion in raccoons ( Procyon lotor) gradually increased each year under the highdensity bait treatment. However, we did not detect a difference in seroconversion between bait density treatments. Virginia opossums ( Didelphis virginiana) were abundant in the study area and were a potentially important nontarget species that competed for oral rabies vaccine baits, but the ratio of opossums to raccoons in this study did not affect rabies virus neutralizing antibody response of the raccoon populations.

摘要

2014年至2016年期间，我们在美国弗吉尼亚州的一个地区研究了以高密度（每公里150个诱饵）投放口服狂犬病疫苗诱饵的效果，该地区在研究之前对口服狂犬病疫苗尚无接触。我们还比较了在一个从未投放过诱饵的地区进行高密度诱饵投放与在一个已连续12年每年进行诱饵投放的地区进行标准密度（每公里75个诱饵）诱饵投放的效果。我们的结果表明，在高密度诱饵处理下，浣熊（北美浣熊）体内的狂犬病病毒血清转化率逐年逐渐提高。然而，我们未检测到诱饵密度处理之间血清转化率的差异。弗吉尼亚负鼠在研究区域数量众多，是争夺口服狂犬病疫苗诱饵的一个潜在重要非目标物种，但本研究中负鼠与浣熊的比例并未影响浣熊种群的狂犬病病毒中和抗体反应。