Pierson W E
University of Washington, Seattle.
Pediatr Clin North Am. 1988 Oct;35(5):1031-40. doi: 10.1016/s0031-3955(16)36546-4.
The early recognition and appropriate management of EIB can allow children and adolescents to participate fully in physical activities and sport. The diagnosis by history of chest congestion, coughing, and decreasing performance with exercise is helpful but is aided by a more systematic questionnaire that can detect otherwise "normal" people with EIB. The diagnosis is documented by performance of an exercise challenge test such as a treadmill or cycloergometer to verify bronchospasm induced by exercise. The management can be accomplished by nonpharmacologic means such as an early vigorous warm-up, the use of a mask for rebreathing warmed air, and participation in a physical training program to increase anaerobic fitness. Pharmacologic management includes the appropriate use of cromolyn sodium, beta-adrenergic agonists, theophylline, ipratromium bromide, and calcium channel blocking agents. In addition, the antihistamine, terfenadine, can be used to block EIB effectively. These pharmacologic agents can be utilized in both national and international competition when approved by the appropriate national governing body or the U.S. Olympic Committee and the International Olympic Committee.
运动诱发支气管收缩(EIB)的早期识别和恰当处理可使儿童和青少年充分参与体育活动和运动。通过运动时胸部闷塞、咳嗽病史以及运动表现下降来诊断是有帮助的,但更系统的问卷有助于诊断,该问卷能够检测出其他方面“正常”的EIB患者。通过进行运动激发试验,如跑步机或蹬车测力计试验,以证实运动诱发的支气管痉挛来记录诊断结果。处理方法可采用非药物手段,如早期积极热身、使用面罩回吸温热空气,以及参加体能训练计划以提高无氧适能。药物治疗包括合理使用色甘酸钠、β - 肾上腺素能激动剂、茶碱、异丙托溴铵和钙通道阻滞剂。此外,抗组胺药特非那定可有效阻断EIB。当获得相应国家管理机构或美国奥委会及国际奥委会批准后,这些药物可用于国内和国际比赛。