Pierson W E
University of Washington, Seattle 98105.
Clin Rev Allergy. 1988 Winter;6(4):443-52.
The early recognition and appropriate management of EIB can allow children and adolescents to fully participate in physical activities and sports. The diagnosis by history of chest congestion, coughing, and decreasing performance with exercise is helpful but is aided by a more systematic questionnaire that can detect otherwise "normal" people with EIB. The diagnosis is documented by performance of an exercise challenge test such as a treadmill or cycloergometer to verify bronchospasm induced by exercise. The management can be accomplished by nonpharmacologic means such as an early vigorous warmup, the use of a mask for rebreathing warmed air, and participation in a physical training program to increase anaerobic fitness. Pharmacologic management includes the appropriate use of cromolyn sodium, beta adrenergic agonists, theophylline, ipratroprium bromide, and calcium channel blocking agents. In addition the antihistamine, terfenadine, can also be utilized to effectively block exercise-induced bronchospasm. These pharmacologic agents can be utilized in both national and international competition when approved by the appropriate national governing body and/or the US Olympic Committee and the International Olympic Committee.
运动诱发性支气管痉挛(EIB)的早期识别和恰当处理可使儿童和青少年充分参与体育活动和运动。通过胸部闷塞、咳嗽病史以及运动时表现下降来诊断是有帮助的,但借助更系统的问卷可发现其他“正常”的EIB患者。通过进行运动激发试验(如跑步机或蹬车测力计试验)以证实运动诱发的支气管痉挛来记录诊断结果。处理方法可通过非药物手段实现,如早期进行剧烈热身、使用面罩回吸温热空气以及参加体能训练计划以提高无氧适能。药物治疗包括合理使用色甘酸钠、β肾上腺素能激动剂、茶碱、异丙托溴铵和钙通道阻滞剂。此外,抗组胺药特非那定也可用于有效阻断运动诱发的支气管痉挛。经适当的国家管理机构和/或美国奥林匹克委员会及国际奥林匹克委员会批准后,这些药物可在国内和国际比赛中使用。