Efron Daryl, Gulenc Alisha, Sciberras Emma, Ukoumunne Obioha C, Hazell Philip, Anderson Vicki, Silk Timothy J, Nicholson Jan M
1 Department of Paediatrics, The University of Melbourne, Parkville, Australia.
2 The Royal Children's Hospital, Parkville, Australia.
J Child Adolesc Psychopharmacol. 2019 Feb;29(1):50-57. doi: 10.1089/cap.2018.0095. Epub 2018 Dec 1.
To determine, in a community-based sample of primary school-aged children meeting diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD), (1) the proportion of children with ADHD treated with medication; (2) predictors of medication use; and (3) the association between medication use and psychological service utilization.
Grade 1 children with ADHD were recruited through 43 schools in Melbourne, Australia, using a two-stage screening and case confirmation procedure. Parent report of medication treatment, clinician diagnosis, and psychological service use were collected at ages 7 and 10 years. Medication use was analyzed by ADHD subtype. Predictors of medication treatment examined included ADHD symptom severity and persistence, externalizing comorbidities, poor academic performance, and social disadvantage. Unadjusted and adjusted logistic regression were used to identify the predictors of medication status.
One hundred seventy-nine children with ADHD were recruited. At baseline, 17.3% had been clinically diagnosed with ADHD, increasing to 37.7% at age 10 years. At baseline, 13.6% were taking ADHD medications, increasing to 25.6% at age 10. Children with the combined and hyperactive-impulsive subtypes were more likely to be taking medication than those with inattentive subtype (age 7: p = 0.002; age 10: p = 0.03). ADHD symptom severity (Conners 3 ADHD Index) at baseline was concurrently and prospectively associated with medication use at both ages (both p = 0.01), and ADHD symptom severity at age 10 was also associated with medication use at age 10 (p = 0.01). Baseline area-level disadvantage was associated with medication use at age 7 (p = 0.04). At 10 years, children receiving medication were more likely, compared with those who were not, to be receiving psychological services (p = 0.001).
In this study, only a minority of children meeting diagnostic criteria for ADHD were diagnosed clinically or treated with ADHD medication by age 10. The strongest predictors of medication treatment were ADHD symptom severity and area disadvantage.
在一个符合注意力缺陷多动障碍(ADHD)诊断标准的小学适龄儿童社区样本中,确定(1)接受药物治疗的ADHD儿童比例;(2)药物使用的预测因素;(3)药物使用与心理服务利用之间的关联。
通过两阶段筛查和病例确认程序,从澳大利亚墨尔本的43所学校招募一年级ADHD儿童。在7岁和10岁时收集家长关于药物治疗、临床医生诊断和心理服务使用情况的报告。按ADHD亚型分析药物使用情况。所检查的药物治疗预测因素包括ADHD症状严重程度和持续性、外化性共病、学业成绩差和社会劣势。采用未调整和调整后的逻辑回归来确定药物使用状态的预测因素。
招募了179名ADHD儿童。基线时,17.3%的儿童被临床诊断为ADHD,10岁时增至37.7%。基线时,13.6%的儿童正在服用ADHD药物,10岁时增至25.6%。与注意力不集中型亚型的儿童相比,合并型和多动冲动型亚型的儿童更有可能服用药物(7岁时:p = 0.002;10岁时:p = 0.03)。基线时的ADHD症状严重程度(康纳斯3 ADHD指数)在两个年龄段均与药物使用同时存在且呈前瞻性关联(均p = 0.01),10岁时的ADHD症状严重程度也与10岁时的药物使用相关(p = 0.01)。基线地区层面的劣势与7岁时的药物使用相关(p = 0.04)。在10岁时,与未接受药物治疗的儿童相比,接受药物治疗的儿童更有可能接受心理服务(p = 0.001)。
在本研究中,到10岁时,只有少数符合ADHD诊断标准的儿童被临床诊断或接受ADHD药物治疗。药物治疗的最强预测因素是ADHD症状严重程度和地区劣势。