Drugging the Mighty Neutrophil in Chronic Obstructive Pulmonary Disease.
作者信息
Fessler Michael B
机构信息
1 National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.
出版信息
Am J Respir Cell Mol Biol. 2019 Apr;60(4):382-383. doi: 10.1165/rcmb.2018-0370ED.
Abstract
摘要
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本文引用的文献
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Direct Inhibitory Effect of the PDE4 Inhibitor Roflumilast on Neutrophil Migration in Chronic Obstructive Pulmonary Disease.罗氟司特对慢性阻塞性肺疾病中性粒细胞迁移的直接抑制作用。
Am J Respir Cell Mol Biol. 2019 Apr;60(4):445-453. doi: 10.1165/rcmb.2018-0065OC.
2
Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.环腺苷酸传感器 EPAC 蛋白及其在心血管功能和疾病中的作用。
Circ Res. 2016 Mar 4;118(5):881-97. doi: 10.1161/CIRCRESAHA.115.306529.
3
Roflumilast Increases Bacterial Load and Dissemination in a Model of Pseudomononas Aeruginosa Airway Infection.罗氟司特在铜绿假单胞菌气道感染模型中增加细菌负荷和播散。
J Pharmacol Exp Ther. 2016 Apr;357(1):66-72. doi: 10.1124/jpet.115.229641. Epub 2016 Feb 10.
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Roflumilast: a review of its use in the treatment of COPD.罗氟司特：其用于慢性阻塞性肺疾病治疗的综述
Int J Chron Obstruct Pulmon Dis. 2016 Jan 6;11:81-90. doi: 10.2147/COPD.S89849. eCollection 2016.
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Disease phenotyping in chronic obstructive pulmonary disease: the neutrophilic endotype.慢性阻塞性肺疾病的疾病表型：中性粒细胞内型
Curr Opin Pulm Med. 2016 Mar;22(2):91-9. doi: 10.1097/MCP.0000000000000238.
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Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.环磷酸腺苷（cAMP）直接激活的交换蛋白（EPAC）可逆转β2-激动剂、皮质类固醇和危重病引起的中性粒细胞功能障碍。
J Allergy Clin Immunol. 2016 Feb;137(2):535-44. doi: 10.1016/j.jaci.2015.07.036. Epub 2015 Sep 18.
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Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease.罗氟司特 N-氧化物逆转慢性阻塞性肺疾病患者中性粒细胞中的皮质激素抵抗。
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Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者外周血中性粒细胞迁移的行为和结构差异。
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