Adamji Mustafa, Day Andrew S
Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.
Intest Res. 2019 Apr;17(2):171-176. doi: 10.5217/ir.2018.00079. Epub 2018 Dec 3.
The role and efficacy of exclusive enteral nutrition (EEN) in the treatment of luminal Crohn's disease (CD) has been well established over the last 2 decades. Consequently, in many centers nutritional therapy is now considered first line therapy in the induction of remission of active CD. However, the use of nutritional therapy in complicated CD has yet to be fully determined. This article aimed to review case reports and clinical trials published in the last decade that have considered and evaluated nutritional therapy in the setting of complicated CD in children and adults. Published literature focusing upon the use of nutritional therapy as part of medical therapy in the management of complicated CD were identified and reviewed. Although there continue to be various interventions utilized for complicated CD, the currently available literature demonstrates that nutritional therapies, especially EEN, have important roles in the management of these complex scenarios. Further assessments, involving large numbers of patients managed with consistent approaches, are required to further substantiate these roles.
在过去20年里，全肠内营养（EEN）在治疗肠腔型克罗恩病（CD）中的作用和疗效已得到充分证实。因此，在许多中心，营养治疗目前被视为诱导活动性CD缓解的一线治疗方法。然而，营养治疗在复杂性CD中的应用尚未完全确定。本文旨在回顾过去十年发表的病例报告和临床试验，这些报告和试验对儿童和成人复杂性CD情况下的营养治疗进行了考量和评估。确定并回顾了将营养治疗作为复杂性CD管理中药物治疗一部分的已发表文献。尽管目前仍有各种干预措施用于复杂性CD，但现有文献表明，营养治疗，尤其是EEN，在这些复杂情况下的管理中具有重要作用。需要进行进一步评估，纳入大量采用一致方法管理的患者，以进一步证实这些作用。
