载脂蛋白基因 rs266729 变异在低热量地中海饮食减肥及心血管危险因素中的作用。

Role of the variant in adiponectin gene rs266729 on weight loss and cardiovascular risk factors after a hypocaloric diet with the Mediterranean pattern.

机构信息

Center of Investigation of Endocrinology and Nutrition, Medical School, Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.

出版信息

Nutrition. 2019 Apr;60:1-5. doi: 10.1016/j.nut.2018.08.018. Epub 2018 Aug 23.

DOI:10.1016/j.nut.2018.08.018

PMID:30508762

Abstract

OBJECTIVES

The role of ADIPOQ gene variants on weight loss after a dietary intervention remain unclear. The aim of this study was to analyze the effects of rs266729 of the ADIPOQ gene on cardiovascular risk factors and adiposity parameters after adherence to a Mediterranean-type hypocaloric diet.

METHOD

Eighty-three obese patients were studied before and after 12 wk on a Mediterranean-type hypocaloric diet. Anthropometric parameters and biochemical profiles were measured. The variant of ADIPOQ gene rs266729 was assessed at basal time by polymerase chain reaction at real time.

RESULTS

Two genotype groups were realized (CC versus CG + GG). The final genotype distribution was 48 patients CC (57.8%), 30 patients CG (36.2%) and 5 patients GG (6%). After dietary intervention with a moderate calorie restriction and in both genotypes, body mass index (BMI), weight, fat mass, systolic blood pressure, and waist circumference decreased. After dietary intervention and in non-G allele carriers (CC versus CG+ GG), glucose (δ: -6.2 ± 1.1 versus -2.9 ± 1.2 mg/dL; P = 0.02), total cholesterol (δ:-15.2 ± 3.1 versus -3.4 ± 2 mg/dL; P = 0.02), low-density lipoprotein cholesterol (δ, -14.9 ± 3.1 versus -4.9 ± 1.2 mg/dL; P = 0.01), insulin levels (δ, -4± 0.6 versus 0.7 ± 0.3 UI/L;P = 0.01), homeostasis model assessment for insulin resistance (δ, -1.6 ± 0.4 versus -0.2 ± 0.4 units; P = 0.01), and adiponectin (δ, -10.4 ± 3.1 versus -1.3 ± 1.0 ng/dL; P = 0.01) improved.

CONCLUSION

After weight loss, the CC genotype of ADIPOQ gene variant (rs266729) is associated with increases in adiponectin levels and decreases of low-density lipoprotein cholesterol, insulin and homeostasis model assessment for insulin resistance after weight loss.

摘要

目的

ADIPOQ 基因变异对饮食干预后体重减轻的作用仍不清楚。本研究的目的是分析 ADIPOQ 基因 rs266729 变异对地中海型低热量饮食依从性后心血管危险因素和肥胖参数的影响。

方法

对 83 例肥胖患者进行了 12 周的地中海型低热量饮食干预前后的研究。测量了人体测量参数和生化指标。在基础时间通过实时聚合酶链反应检测 ADIPOQ 基因 rs266729 变异。

结果

实现了两种基因型组（CC 与 CG+GG）。最终的基因型分布为 48 例 CC（57.8%），30 例 CG（36.2%）和 5 例 GG（6%）。中等热量限制的饮食干预后，在两种基因型中，体重指数（BMI）、体重、体脂、收缩压和腰围均降低。在饮食干预和非 G 等位基因携带者（CC 与 CG+GG）中，葡萄糖（变化：-6.2±1.1 与-2.9±1.2mg/dL；P=0.02）、总胆固醇（变化：-15.2±3.1 与-3.4±2mg/dL；P=0.02）、低密度脂蛋白胆固醇（变化：-14.9±3.1 与-4.9±1.2mg/dL；P=0.01）、胰岛素水平（变化：-4±0.6 与 0.7±0.3UI/L；P=0.01）、胰岛素抵抗的稳态模型评估（变化：-1.6±0.4 与-0.2±0.4 单位；P=0.01）和脂联素（变化：-10.4±3.1 与-1.3±1.0ng/dL；P=0.01）均有改善。