Fomin Dmitrij, Baranauskaite Vilma, Usaviciene Emilija, Sumkovskaja Alina, Laima Sigitas, Jasulaitis Algimantas, Minkuviene Zita Nijole, Chmieliauskas Sigitas, Stasiuniene Jurgita
Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Sciences of the Faculty of Medicine of Vilnius University.
State Forensic Medicine Service, Vilnius, Lithuania.
Medicine (Baltimore). 2018 Nov;97(48):e13449. doi: 10.1097/MD.0000000000013449.
Carfentanyl, an ultra-potent synthetic opioid, is approved for use only in veterinary medicine as a tranquilizing agent. However, many cases of human poisoning with carfentanyl have recently appeared in the news with limited information given and scientific literature provides only 1 case of documented human exposure to carfentanyl.Fifteen cases of death from drug overdoses with carfentanyl involvement are being presented. Fifteen blood and urine samples have been taken for alcohol and drug testing. Headspace gas chromatography was used for alcohol detection. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and liquid chromatography-time-of-flight mass spectrometry (LC/MS TOF) system was used for drug detection.Sixty-three cases of death from poisoning with drugs have been tested for carfentanyl in the State Forensic Medicine Service. Fifteen of them were positive for carfentanyl.The cases mentioned above show that carfentanyl exposure causes signs and symptoms similar to other opioid toxicity. Carfentanyl intoxication may even be fatal if appropriate treatment is not available. Therefore, nowadays it is very important to draw forensic medicine expert's attention to new substances in drug trade.
卡芬太尼是一种超强效合成阿片类药物，仅被批准作为镇静剂用于兽医学。然而，最近新闻中出现了许多卡芬太尼致人中毒的案例，但所提供的信息有限，且科学文献仅记载了1例人类接触卡芬太尼的案例。本文报告了15例涉及卡芬太尼的药物过量致死案例。采集了15份血液和尿液样本进行酒精和药物检测。采用顶空气相色谱法检测酒精。采用液相色谱-串联质谱法（LC-MS/MS）和液相色谱-飞行时间质谱法（LC/MS TOF）系统检测药物。国家法医学服务机构对63例药物中毒死亡案例进行了卡芬太尼检测。其中15例卡芬太尼检测呈阳性。上述案例表明，接触卡芬太尼会引发与其他阿片类药物中毒相似的体征和症状。如果没有适当的治疗，卡芬太尼中毒甚至可能致命。因此，如今提请法医学专家关注毒品交易中的新物质非常重要。
