MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.
Eye Center, Second Affiliated Hospital, School of Medicine , Zhejiang University , Hangzhou 310027 , China.
ACS Nano. 2018 Dec 26;12(12):12347-12356. doi: 10.1021/acsnano.8b06321. Epub 2018 Dec 5.
Transition metal dichalcogenide (TMD) nanosheets have evoked enormous research enthusiasm and have shown increased potentials in the biomedical field. However, a great challenge lies in high-throughput, large-scale, and eco-friendly preparation of TMD nanosheet dispersions with high quality. Herein, we report a universal polyphenol-assisted strategy to facilely exfoliate various TMDs into monolayer or few-layer nanosheets. By optimizing the exfoliation condition of molybdenum disulfide (MoS), the yield and concentration of as-exfoliated nanosheets are up to 60.5% and 1.21 mg/mL, respectively. This is the most efficient aqueous exfoliation method at present and is versatile for the choices of polyphenols and TMD nanomaterials. The as-exfoliated MoS nanosheets possess superior biomedical stability as nanocarriers to load antibiotic drugs. They show a high photothermal conversion effect and thus induce a synergetic effect of chemotherapy and photothermal therapy to harvest enhanced antibiofilm activity under near-infrared (NIR) light. All these results offer an appealing strategy toward the synthesis and application of ultrathin TMD nanosheets, with great implications for their development.
过渡金属二卤化物（TMD）纳米片引起了人们极大的研究热情，并在生物医学领域显示出了更大的潜力。然而，目前面临的一个巨大挑战是如何高通量、大规模、环保地制备具有高质量的 TMD 纳米片分散体。在此，我们报告了一种通用的多酚辅助策略，可简便地将各种 TMD 剥离成单层或少数层纳米片。通过优化二硫化钼（MoS）的剥离条件，所得剥离纳米片的产率和浓度分别高达 60.5%和 1.21mg/mL。这是目前最有效的水相剥离方法，对多酚和 TMD 纳米材料的选择具有通用性。剥离得到的 MoS 纳米片作为纳米载体具有优异的生物医学稳定性，可负载抗生素药物。它们表现出高的光热转换效应，因此在近红外（NIR）光下能够引发化学治疗和光热治疗的协同作用，从而获得增强的抗生物膜活性。所有这些结果为超薄 TMD 纳米片的合成和应用提供了一种有吸引力的策略，对其发展具有重要意义。
