Rheumatology Department, Centre Hospitalier Universitaire de Nantes, Nantes, France.
INSERM UMR 1238, Faculty of Biology of Nantes, Nantes, France.
Arthritis Res Ther. 2018 Dec 3;20(1):265. doi: 10.1186/s13075-018-1762-1.
The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.
Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.
Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.
We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.
本项全球合作旨在通过 EULAR 滑膜炎研究组（ESSG）和 OMERACT 滑膜组织活检组，制定一套针对滑膜活检的共识性分析项目，以应用于临床实践和转化研究。
采用改良 Delphi 法征求意见。在 12 个月内进行了三轮。研究人员向参与者发送了一份书面问卷，其中包含分为两部分的项目。项目是基于范围综述确定并制定的。问卷的第一部分涉及临床实践中的滑膜活检，包括五个小节；第二部分涉及转化研究，包括六个小节。每位参与者均需对每个项目进行 5 分制的李克特评分。评分中位数大于 3.5 分且达成率大于等于 70%的项目，将进入下一轮。最后一轮于 2017 年 6 月在 EULAR 进行了口头讨论。
通过电子邮件联系了 19 个中心的 27 名参与者，有 17 个中心的 20 名参与者做出了回复。对后续轮次的回复率为 100%。与临床实践相关的第一部分中，有 20/44 项（45.5%）被选中；与转化研究相关的第二部分中，有 18/43 项（41.9%）被选中，作为最终项目集。
本文提出了一套用于临床实践和转化研究中滑膜活检的共识性分析项目。
