长链非编码 RNA LCPAT1 参与 CSE 诱导的 DNA 损伤。
LncRNA LCPAT1 is involved in DNA damage induced by CSE.
机构信息
Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, USA.
出版信息
Biochem Biophys Res Commun. 2019 Jan 8;508(2):512-515. doi: 10.1016/j.bbrc.2018.11.171. Epub 2018 Nov 30.
Cigarette smoking plays an important role in the process of lung cancer, during which DNA damage is proved to be involved. Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. In the present study, we investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. Our results indicate that LCPAT1, through RCC2 is involved in the CSE-induced DNA damage providing new insight into the lung carcinogenesis related to cigarette smoking.
吸烟在肺癌的发生过程中起着重要作用，在此过程中已证实 DNA 损伤的存在。非编码 RNA 被发现参与了由香烟烟雾引起的 DNA 损伤和修复过程。在本研究中，我们调查了长链非编码 RNA LCPAT1 在 CSE 诱导的 Beas-2B 细胞 DNA 损伤中的作用。我们的结果表明，LCPAT1 通过 RCC2 参与了 CSE 诱导的 DNA 损伤，为与吸烟有关的肺癌发生提供了新的见解。
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