Saleh Tarek A, Adams Morag, McDermott Bill, Claridge Kate G, Ewings Paul
Taunton and Somerset Hospital, Musgrove Park, Taunton, UK.
Clin Exp Ophthalmol. 2006 Aug;34(6):516-20. doi: 10.1111/j.1442-9071.2006.01266.x.
To assess the effects of central corneal thickness (CCT) and corneal curvature (CC) on the measurements of intraocular pressure (IOP) using Goldmann applanation tonometer (GAT) and the ocular blood flow pneumatonometer (OBFT).
104 patients were recruited from a glaucoma clinic. The CCT was measured using ultrasound pachymetry and the mean radius of CC using a keratometer. The IOP of each eye was measured using both GAT and the OBFT in a random order. Right eyes only were analysed for statistical purposes.
The mean (+/-SD) IOP by GAT and OBFT was 18.2 mmHg (+/-4.4) and 18.2 mmHg (+/-4.0), respectively, with no statistically significant difference. IOP measurement with both instruments varied with CCT and CC. GAT showed an IOP increase of 0.40 mmHg per 10 microm increase of CCT and OBFT showed an increase of 0.38 mmHg in IOP per 10 microm increase of CCT. Multiple regression analysis showed that the effect of CCT was statistically significant (P<0.001) on IOP recorded by both the GAT and OBFT but CC did not have a statistically significant effect on IOP recordings performed by either technique.
IOP measurements by GAT and OBFT are positively correlated with CCT with both tonometers being similarly affected. There was no significant correlation between CC and IOP measured by either tonometer.
评估中央角膜厚度（CCT）和角膜曲率（CC）对使用戈德曼压平眼压计（GAT）和眼血流气压眼压计（OBFT）测量眼压（IOP）的影响。
从一家青光眼诊所招募了104名患者。使用超声测厚法测量CCT，使用角膜曲率计测量CC的平均半径。每只眼睛的眼压通过GAT和OBFT以随机顺序测量。仅对右眼进行统计分析。
GAT和OBFT测得的平均（±标准差）眼压分别为18.2 mmHg（±4.4）和18.2 mmHg（±4.0），无统计学显著差异。两种仪器测量的眼压随CCT和CC而变化。GAT显示CCT每增加10微米眼压升高0.40 mmHg，OBFT显示CCT每增加10微米眼压升高0.38 mmHg。多元回归分析表明，CCT对GAT和OBFT记录的眼压有统计学显著影响（P<0.001），但CC对两种技术测量的眼压记录均无统计学显著影响。
GAT和OBFT测量的眼压与CCT呈正相关，两种眼压计受影响程度相似。两种眼压计测量的CC与眼压之间均无显著相关性。
