Büchler M, Malfertheiner P, Eiberle E, Friess H, Nustede R, Schusdziarra V, Feurle G E, Beger H G
Department of General Surgery, University of Ulm, Federal Republic of Germany.
Pancreas. 1988;3(4):477-83. doi: 10.1097/00006676-198808000-00018.
It has been shown that the large bowel contains substances with a potential to inhibit exocrine pancreatic function. Following large bowel removal in rats, there is an increase of pancreatic weight, digestive enzyme concentration, and secretion capacity in vitro. To evaluate the role of various GI hormones in the exocrine pancreatic adaptation following colectomy, we measured plasma cholecystokinin (CCK), neurotensin, glucagon, and insulin after meal stimulation. The test meal was applied via a transabdominal gastric tube in eight colectomized Wistar rats after a median of 18 days following surgery. Ten rats with a gastric tube without previous bowel surgery served as controls. After large bowel removal, there was impaired glucose tolerance and attenuated plasma insulin secretion. Baseline plasma glucagon levels were increased after colon removal, whereas the total postprandial glucagon release was decreased. Baseline and postprandial neurotensin values were comparable in both the experimental and control animals. Baseline and postprandial CCK plasma levels were intensely increased in the colectomized rats. It is assumed that the baseline and postprandial CCK pattern in rats after subtotal colectomy is responsible for exocrine pancreatic adaptation.
研究表明，大肠中含有具有抑制胰腺外分泌功能潜力的物质。大鼠大肠切除术后，胰腺重量、消化酶浓度及体外分泌能力均会增加。为评估各种胃肠激素在结肠切除术后胰腺外分泌适应性中的作用，我们在进食刺激后测量了血浆胆囊收缩素（CCK）、神经降压素、胰高血糖素和胰岛素。在18只接受结肠切除术的Wistar大鼠术后中位时间18天后，通过经腹胃管给予试验餐。10只插有胃管但未接受过肠道手术的大鼠作为对照。大肠切除术后，葡萄糖耐量受损，血浆胰岛素分泌减弱。结肠切除术后，基础血浆胰高血糖素水平升高，而餐后胰高血糖素总释放量降低。实验动物和对照动物的基础及餐后神经降压素值相当。结肠切除术后大鼠的基础及餐后CCK血浆水平显著升高。推测大鼠次全结肠切除术后的基础及餐后CCK模式是胰腺外分泌适应性的原因。
