von Schönfeld J, Müller M K, Rünzi M, Geling M, Neisius I, Kleimann J, Goebell H
Department of Gastroenterology, University of Essen, Germany.
Metabolism. 1993 May;42(5):552-5. doi: 10.1016/0026-0495(93)90211-6.
Pancreastatin was isolated from porcine pancreas in 1986 and has been shown to inhibit insulin release and exocrine pancreatic secretion in vivo. In the isolated perfused rat pancreas, we investigated its effect on the exocrine pancreas and evaluated its indirect effects mediated via the islet-acinar axis. In the presence of 16.7 mmol/L glucose, 20 pmol/L, 200 pmol/L, and 2 nmol/L pancreastatin reduced insulin release but did not affect exocrine pancreatic secretion stimulated by cholecystokinin (CCK), secretin, or bombesin. Pancreastatin also failed to affect unstimulated exocrine pancreatic secretion. In the presence of 1.7 mmol/L glucose, 200 pmol/L and 2 nmol/L pancreastatin inhibited glucagon release and potentiated CCK-stimulated exocrine pancreatic secretion. Inhibition of glucagon release and augmentation of exocrine pancreatic secretion may be independent phenomena, but they could be linked by the islet-acinar axis. Thus we speculate that a pancreastatin-induced inhibition of glucagon release may indirectly have caused augmentation of exocrine pancreatic secretion.
胰抑制素于1986年从猪胰腺中分离出来，已被证明在体内可抑制胰岛素释放和胰腺外分泌。在离体灌注的大鼠胰腺中，我们研究了其对胰腺外分泌的影响，并评估了其通过胰岛-腺泡轴介导的间接作用。在存在16.7 mmol/L葡萄糖的情况下，20 pmol/L、200 pmol/L和2 nmol/L的胰抑制素可降低胰岛素释放，但不影响胆囊收缩素（CCK）、促胰液素或蛙皮素刺激的胰腺外分泌。胰抑制素也未能影响未受刺激的胰腺外分泌。在存在1.7 mmol/L葡萄糖的情况下，200 pmol/L和2 nmol/L的胰抑制素可抑制胰高血糖素释放，并增强CCK刺激的胰腺外分泌。胰高血糖素释放的抑制和胰腺外分泌的增强可能是独立的现象，但它们可能通过胰岛-腺泡轴联系起来。因此，我们推测胰抑制素诱导的胰高血糖素释放抑制可能间接导致了胰腺外分泌的增强。
