Faculty of Medical Sciences, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle Upon Tyne, UK.
EMBO J. 2018 Dec 14;37(24). doi: 10.15252/embj.2018101084. Epub 2018 Dec 3.
The IκB kinase (IKK) complex is best known as the core regulator of NF‐κB signalling. Recent work from Mikuda reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P‐body formation and the stability of numerous mRNAs, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.
IKK 激酶（IKK）复合物作为 NF-κB 信号转导的核心调节剂而闻名。最近，Mikuda 的研究揭示了 IKK 在调节 mRNA 稳定性方面的新的、意想不到的功能。通过与 mRNA 去帽复合物的关键组成部分 EDC4 相互作用并磷酸化它，IKK 调节 P 体的形成和许多 mRNA 的稳定性，包括许多编码炎症细胞因子的 mRNA。因此，IKK 的激活可以更普遍地被认为是通过 mRNA 稳定性和转录来编程细胞对应激和感染的反应。
