Benvenga M J, Spaulding T C
Pharmacology Group, Anaquest, BOC Health Care, Murray Hill, NJ 07974.
Pharmacol Biochem Behav. 1988 May;30(1):205-7. doi: 10.1016/0091-3057(88)90445-5.
MK-801, a reported N-methyl-D-aspartate (NMDA) antagonist with affinity for the phencyclidine (PCP) receptor, injected intravenously in mice before a training trial in a passive avoidance procedure, produced a similar amnesic effect to that produced by the standard amnesic agent scopolamine. Compared to vehicle-treated mice, each drug produced significant amnesia, yet the potency of MK-801 was 40 times that of scopolamine. This result with the MK-801 is consistent with previous reports that drugs which act at PCP recognition sites within the brain produce memory impairing effects in rodents.
MK-801是一种已报道的对苯环利定（PCP）受体具有亲和力的N-甲基-D-天冬氨酸（NMDA）拮抗剂，在被动回避程序的训练试验前静脉注射给小鼠，产生了与标准失忆剂东莨菪碱类似的失忆效果。与用赋形剂处理的小鼠相比，每种药物都产生了显著的失忆，但MK-801的效力是东莨菪碱的40倍。MK-801的这一结果与之前的报道一致，即在大脑中作用于PCP识别位点的药物会对啮齿动物产生记忆损害作用。
