Reynaud R, Emberger J M, Ciurana A J, Blanc F, Bertrand L
Schweiz Med Wochenschr. 1978 Mar 4;108(9):325-31.
A report is presented on four cases of angioimmunoblastic lymphadenopathy. In this recently individualized entity, adenomegaly with fever and cutaneous eruption is associated with polyclonal hypergammaglobulinemia and autoimmunization, especially of anti-erythrocytic type. The lymph nodes are homogenized by a lymphoplasmo-immunoblastic granuloma with angiogenesis. The disease could be attributed to hyperplasia of B lymphocytes with a deficit of T cells, which would explain the autoimmunization. It appears in some cases to be triggered by accidents of drug intolerance. Prognosis is poor and the course of the disease is nearly always fatal in the long or short term. It is difficult to ascertain whether prolonged remissions, either spontaneous or therapeutic, can be considered actual cures.
本文报告了4例血管免疫母细胞性淋巴结病。在这个最近被个体化定义的疾病实体中，淋巴结肿大伴发热和皮疹与多克隆高球蛋白血症及自身免疫反应相关，尤其是抗红细胞类型的自身免疫反应。淋巴结被伴有血管生成的淋巴浆细胞免疫母细胞性肉芽肿所浸润。该疾病可归因于B淋巴细胞增生伴T细胞缺陷，这可以解释自身免疫反应的发生。在某些病例中，它似乎是由药物不耐受事件引发的。预后较差，疾病进程几乎总是在长期或短期内致命。很难确定无论是自发的还是治疗诱导的长期缓解是否可被视为真正的治愈。
