Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
Disabil Rehabil. 2020 Jan;42(1):36-43. doi: 10.1080/09638288.2018.1514664. Epub 2018 Dec 4.
To systematically review literature for interventional studies and their impact on autonomic dysfunction assessed by heart rate variability in cancer patients. Research was conducted using the databases Medline/Pubmed, Scopus, and Web of science from their inception to October 2017. Original articles with an interventional design that reported changes in at least one heart rate variability parameter as outcome parameter were included and described. Ten studies were identified as eligible for subsequent analysis. The main application field in oncological therapy setting was music therapy intervention, Traditional Chinese Medicine related treatments, exercise interventions, relaxation, and myofascial release techniques. Breast cancer was the most frequently described single cancer entity. Heart rate variability recording was performed with standard electrocardiography devices or wearable heart rate monitors, within a time range between 5 and 20 min and a sampling rate varying from 200 to 1000 Hz. No adverse events were reported in all studies. Supportive therapy modalities may have the potential to enhance vegetative functioning. In this context, heart rate variability analysis appears to be an easily applicable and safe method to evaluate cancer related autonomic dysfunction. More large prospective multicentre randomised controlled trials are needed.Implication for rehabilitationMost cancer patients face autonomic dysfunction due to the disease itself the applied treatments or combination of both.HRV measurement is an easy and safe method to asses autonomic dysfunction.Supportive treatments targeting on an elevation of the vagal tone and autonomic balance in general might have beneficial effects for cancer patients.
系统性回顾文献中关于介入性研究及其对癌症患者自主神经功能障碍（通过心率变异性评估）的影响。研究使用 Medline/Pubmed、Scopus 和 Web of science 数据库，检索时间从建库至 2017 年 10 月。纳入并描述了采用介入性设计，且报告至少有一个心率变异性参数作为结果参数发生变化的原始文章。有 10 项研究被确定为随后分析的合格研究。在肿瘤治疗环境中的主要应用领域是音乐治疗干预、中医药相关治疗、运动干预、放松和肌筋膜松解技术。乳腺癌是最常描述的单一癌症实体。心率变异性记录是在标准心电图设备或可穿戴心率监测器上进行的，记录时间范围在 5 到 20 分钟之间，采样率从 200 到 1000Hz 不等。所有研究均未报告不良事件。支持性治疗方法可能具有增强植物性功能的潜力。在这种情况下，心率变异性分析似乎是一种易于应用且安全的方法，可用于评估癌症相关的自主神经功能障碍。需要更多的大型前瞻性多中心随机对照试验。康复的意义大多数癌症患者由于疾病本身、所应用的治疗方法或两者的结合而面临自主神经功能障碍。HRV 测量是评估自主神经功能障碍的一种简单、安全的方法。针对提高迷走神经张力和自主平衡的支持性治疗可能对癌症患者有益。
