Dogru Mahmut, Kirmizibekmez Heves, Yesiltepe Mutlu Rahime Gul, Aktas Alev, Ozturkmen Seda
Department of Pediatrics, Zeynep Kamil Maternity and Children's Disease Training and Research Hospital, Istanbul, Turkey.
Int Arch Allergy Immunol. 2014;164(4):319-25. doi: 10.1159/000366279. Epub 2014 Sep 23.
Both asthma and vitamin D deficiency are common among children. The results from studies examining the relationship between them are contradictory. The aim of this study is to determine the relationship between the clinical parameters of asthma and vitamin D status in children.
One hundred and twenty children diagnosed with asthma and followed-up in our hospital were included in the study. The control group included 74 children with no evidence of allergic disease. The eosinophil counts, IgE levels and serum 25 OH cholecalciferol [25(OH)D] levels were measured.
The patient group consisted of 73 (60.8%) males and 47 (39.2%) females with a mean age of 4.4 ± 1.2 years. There was no significant difference between the patient and control groups with respect to gender and age. The mean 25(OH)D level was 21.49 ± 7.74 ng/ml in the study group and 23.94 ± 8.97 ng/ml in the control group, and this difference was not significant (p = 0.094). The patients with asthma were grouped according to their vitamin D status as 'deficient' (group 1), 'insufficient' (group 2) and 'normal' (group 3). The sociodemographic features, duration of illness, number of hospitalizations, number of sensitivities to allergens, eosinophil count and serum IgE levels were not found to be different between the groups. However, the total number of exacerbations, asthma severity and systemic glucocorticoid need in the previous year were significantly higher in the deficiency group (p < 0.05).
Vitamin D levels were not significantly different in patients with asthma. Vitamin D deficiency was common in the study group as well as in the control group. The clinical severity of disease, the number of exacerbations and the systemic glucocorticoid need were related to vitamin D level.
哮喘和维生素D缺乏在儿童中都很常见。研究两者之间关系的结果相互矛盾。本研究的目的是确定儿童哮喘临床参数与维生素D状态之间的关系。
本研究纳入了120例在我院诊断为哮喘并接受随访的儿童。对照组包括74例无过敏性疾病证据的儿童。测量嗜酸性粒细胞计数、免疫球蛋白E（IgE）水平和血清25羟胆钙化醇[25(OH)D]水平。
患者组包括73名（60.8%）男性和47名（39.2%）女性，平均年龄为4.4±1.2岁。患者组和对照组在性别和年龄方面无显著差异。研究组的平均25(OH)D水平为21.49±7.74纳克/毫升，对照组为23.94±8.97纳克/毫升，差异无统计学意义（p=0.094）。哮喘患者根据其维生素D状态分为“缺乏”（第1组）、“不足”（第2组）和“正常”（第3组）。各组之间的社会人口学特征、病程、住院次数、对过敏原的敏感次数、嗜酸性粒细胞计数和血清IgE水平均无差异。然而，缺乏组在前一年的发作总数、哮喘严重程度和全身糖皮质激素需求显著更高（p<0.05）。
哮喘患者的维生素D水平无显著差异。维生素D缺乏在研究组和对照组中都很常见。疾病的临床严重程度、发作次数和全身糖皮质激素需求与维生素D水平有关。
