College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, People's Republic of China.
Org Biomol Chem. 2018 Dec 12;16(48):9472-9476. doi: 10.1039/c8ob02539h.
Since esters are important organic synthesis intermediates, an environmentally friendly oxone catalyzed-esterification of carboxylic acids with alcohols has been developed. A series of carboxylic acid esters are obtained in high yield. This strategy requires mild reaction conditions, providing an attractive alternative for the construction of valuable carbonyl esters. Electron-rich and electron-deficient groups are compatible with the standard conditions and a variety of substrates are demonstrated. Moreover, the reaction could easily be adapted to typical prodrugs, drugs and gram-scale synthesis.
由于酯类是重要的有机合成中间体，因此开发了一种绿色环保的过氧单硫酸盐催化羧酸与醇的酯化反应。该方法可以高产率得到一系列羧酸酯。该策略所需的反应条件温和，为构建有价值的羰基酯提供了一种有吸引力的替代方法。富电子和缺电子基团与标准条件兼容，并且可以证明多种底物适用。此外，该反应可以很容易地适用于典型的前药、药物和克级规模的合成。
