同义密码子的遗传差异为从猪到人传播戊型肝炎病毒提供了新的线索。
The genetic divergences of codon usage shed new lights on transmission of hepatitis E virus from swine to human.
机构信息
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, Gansu, China; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Room Na-1011, s-Gravendijkwal 230, NL-3015 CE, Rotterdam, the Netherlands; State Key Laboratory of Veterinary Etiological Biology, Chinese Academy of Agricultural Sciences, Lanzhou Veterinary Research Institute, Lanzhou, 730046, Gansu, China.
State Key Laboratory of Veterinary Etiological Biology, Chinese Academy of Agricultural Sciences, Lanzhou Veterinary Research Institute, Lanzhou, 730046, Gansu, China.
出版信息
Infect Genet Evol. 2019 Mar;68:23-29. doi: 10.1016/j.meegid.2018.11.024. Epub 2018 Dec 2.
Hepatitis E virus (HEV) is an important pathogen causing public health burden. Swine has been recognized as a main reservoir. Interestingly, genotype 1 HEV only infects human; whereas genotype 3 and 4 are zoonotic. However, there is a lack of in-depth understanding in respect to the transmission from swine to human. Codon usage patterns generally participate in viral survival and fitness towards its hosts. We have analyzed codon usage patterns of the three open reading frames (ORFs) for 243 full-length genomes of HEV genotypes 1, 3 and 4. The divergence of synonymous codon usage patterns is different in each ORF for genotypes 1, 3 and 4, but the genotype-specific codon usage bias in genotype 1 is stronger than those of genotypes 3 and 4. In respect to genotypes 3 and 4, compared with strains isolated from human, HEV isolated from swine shows appreciable variation in adaptation of codon usages to human or swine. These results may help to understand the transmission and host adaptation of HEV genotypes 3 and 4 from swine to human.
戊型肝炎病毒（HEV）是造成公共卫生负担的重要病原体。猪已被认为是主要的储存宿主。有趣的是，基因型 1 的 HEV 仅感染人类；而基因型 3 和 4 则是人畜共患病。然而，对于其从猪传播到人类的机制，我们还缺乏深入的了解。密码子使用模式通常参与病毒在其宿主中的存活和适应性。我们分析了基因型 1、3 和 4 的 243 个全长基因组的三个开放阅读框（ORF）的密码子使用模式。对于基因型 1、3 和 4，每个 ORF 的同义密码子使用模式的差异不同，但基因型 1 的基因型特异性密码子使用偏好比基因型 3 和 4 更强。对于基因型 3 和 4，与从人类分离的菌株相比，从猪分离的 HEV 在适应人类或猪的密码子使用方面表现出明显的差异。这些结果可能有助于理解 HEV 基因型 3 和 4 从猪传播到人类的传播和宿主适应性。
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