Li Pengfei, Ji Yunpeng, Li Yunlong, Ma Zhongren, Pan Qiuwei
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, China.
One Health. 2021 Dec 14;14:100362. doi: 10.1016/j.onehlt.2021.100362. eCollection 2022 Jun.
Zoonotic transmission of hepatitis E virus (HEV), in particular the genotype (GT) 3 and GT4 strains, constitutes a major one health issue. Swine serves as an important reservoir and the processed pork products essentially contribute to foodborne transmission. This study comprehensively estimated HEV prevalence in domestic pigs, wild boars, and pork products. At global level, we found nearly 60% domestic pigs and 27% wild boars have ever encountered HEV infection based seroprevalence rate. Nearly 13% domestic and 9.5% wild swine are actively infected based on HEV RNA positivity. Importantly, about 10% of commercial pork products are HEV RNA positive, although available data are limited in this respect. Our results indicate the high prevalence rate of HEV infection in pigs and widespread contamination in pork products, although there are substantial variations at regional and country levels. These findings are important for better understanding the global epidemiology and clinical burden of HEV infection in human population related to zoonotic transmission.
戊型肝炎病毒（HEV）的人畜共患传播，尤其是基因型（GT）3和GT4毒株，构成了一个重大的“同一个健康”问题。猪是重要的储存宿主，加工猪肉产品是食源性传播的主要来源。本研究全面评估了家猪、野猪和猪肉产品中HEV的流行情况。在全球范围内，基于血清阳性率，我们发现近60%的家猪和27%的野猪曾感染过HEV。基于HEV RNA阳性率，近13%的家猪和9.5%的野猪处于活跃感染状态。重要的是，约10%的商业猪肉产品HEV RNA呈阳性，尽管这方面的现有数据有限。我们的结果表明，尽管在区域和国家层面存在显著差异，但猪中HEV感染的流行率很高，猪肉产品中污染广泛。这些发现对于更好地了解与动物源性传播相关的人类戊型肝炎病毒感染的全球流行病学和临床负担具有重要意义。
