Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Dermatol Ther. 2019 Mar;32(2):e12796. doi: 10.1111/dth.12796. Epub 2018 Dec 13.
Recently, advances in understanding the etiology of urticaria and updates of diagnostic and therapeutic management guidelines have drawn attention to chronic urticaria (CU) morbidity. The present study aimed to evaluate Iranian dermatologists' practice and real life management of CU patients. A total of 35 dermatologists and 443 patients were included in the study. Number of female patients was 321 (72.5%). Mean (standard deviation) age of the study patients was 38 (13) years and the median (inter quartile range) of disease duration was 12 (6-48) months. Severity of patients' symptoms was mild for 32.1%, moderate for 38.7%, severe for 18.8%, and 10.4% of them had no evident signs or symptoms. The most common diagnostic methods were physical examination (96.6%), differential blood count (83.5%), erythrocyte sedimentation rate (77.4%), and C-reactive protein (62.8%). The number of dermatologists prescribed nonsedating antihistamines (nsAH) in regular dose and high dose mono therapy were 26 (74%) and 6 (17%), respectively. About 66% of dermatologists were familiar with British Association of Dermatologists (BAD) guideline. The most common first-line treatment for CU by Iranian dermatologists was nonsedating antihistamines in regular or high doses. The real-life management of patients with CU in Iran was in accordance with the available practice guidelines.
最近，对荨麻疹病因的理解以及诊断和治疗管理指南的更新引起了人们对慢性荨麻疹（CU）发病率的关注。本研究旨在评估伊朗皮肤科医生对 CU 患者的实践和实际管理情况。共有 35 名皮肤科医生和 443 名患者入组本研究。女性患者 321 名（72.5%）。研究患者的平均（标准差）年龄为 38（13）岁，疾病持续时间的中位数（四分位间距）为 12（6-48）个月。患者症状的严重程度为轻度占 32.1%，中度占 38.7%，重度占 18.8%，10.4%的患者无明显症状或体征。最常见的诊断方法是体格检查（96.6%）、全血细胞计数（83.5%）、红细胞沉降率（77.4%）和 C 反应蛋白（62.8%）。26 名（74%）皮肤科医生常规剂量和高剂量单药治疗开非镇静性抗组胺药（nsAH），6 名（17%）医生开抗组胺药。约 66%的皮肤科医生熟悉英国皮肤病学会（BAD）指南。伊朗皮肤科医生治疗 CU 的一线治疗方法通常是常规剂量或高剂量的非镇静性抗组胺药。伊朗 CU 患者的实际管理符合现有实践指南。
