Goode S M, Hertzmark E, Steinert R F
Department of Ophthalmology, Harvard Medical School, Boston.
Am J Ophthalmol. 1988 Oct 15;106(4):463-6. doi: 10.1016/0002-9394(88)90884-7.
Using a simple mathematical model, we calculated the risk for a patient undergoing penetrating keratoplasty to receive a cornea from a human immunodeficiency virus-infected donor despite negative results on serologic testing of donor serum. This error in serologic testing occurred when false-negative results were obtained from the enzyme-linked immunosorbent assay used to screen donor corneas for human immunodeficiency virus exposure. The average risk of transplanting an infected cornea was low, 0.03%, but increased by a factor of ten when donor tissue from donors at high risk for AIDS was used. Current screening procedures are probably adequate to prevent transmission of human immunodeficiency virus, but increased vigilance for high-risk donor populations may be appropriate.
我们使用一个简单的数学模型，计算了穿透性角膜移植患者接受来自人类免疫缺陷病毒感染供体的角膜的风险，尽管供体血清的血清学检测结果为阴性。当用于筛查供体角膜是否暴露于人类免疫缺陷病毒的酶联免疫吸附测定获得假阴性结果时，就会出现这种血清学检测错误。移植受感染角膜的平均风险较低，为0.03%，但使用来自艾滋病高风险供体的组织时，风险会增加10倍。目前的筛查程序可能足以预防人类免疫缺陷病毒的传播，但对高风险供体人群提高警惕可能是合适的。
