Eidemüller Markus, Simonetto Cristoforo, Kundrát Pavel, Ulanowski Alexander, Shemiakina Elena, Güthlin Denise, Rennau Hannes, Remmele Julia, Hildebrandt Guido, Wolf Ulrich
Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstädter Landstr. 1, Neuherberg, Germany.
Klinik und Poliklinik für Strahlentherapie, Universitätsmedizin Rostock, Südring 75, Rostock, Germany.
Radiat Prot Dosimetry. 2019 May 1;183(1-2):259-263. doi: 10.1093/rpd/ncy219.
Breast-cancer radiotherapy reduces the recurrence rates and improves patient survival. However, it also increases the incidence of second cancers and of heart disease. These radiation-induced long-term health risks become increasingly important with improved cure rates and prolonged patient survival. Radiation doses to nearby as well as distant organs strongly vary between different irradiation techniques and among individual patients. To provide personalized lifetime risk estimates, the German national project PASSOS combines individual anatomy, dosimetric estimates, organ-specific low- and high-dose risk models and personal risk factors such as smoking. A dedicated software tool is under development to assist clinical decision-making processes.
乳腺癌放疗可降低复发率并提高患者生存率。然而，它也会增加二次癌症和心脏病的发病率。随着治愈率的提高和患者生存期的延长，这些辐射诱发的长期健康风险变得越来越重要。不同照射技术以及个体患者之间，对附近和远处器官的辐射剂量差异很大。为了提供个性化的终身风险评估，德国国家项目PASSOS结合了个体解剖结构、剂量学评估、器官特异性低剂量和高剂量风险模型以及吸烟等个人风险因素。目前正在开发一种专用软件工具，以协助临床决策过程。
