Freedman M H, Estrov Z, Chan H S
Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Canada.
Am J Pediatr Hematol Oncol. 1988 Fall;10(3):261-7. doi: 10.1097/00043426-198823000-00016.
Juvenile chronic myelogenous leukemia (JCML) is a malignant hematopoietic disorder of monocyte-histiocyte lineage that affects children less than 4 years of age. Since the disease represents only 2% of all childhood leukemias, experience with it has been limited even in large centers. This review summarizes our 10 year institutional study of JCML as well as a comprehensive literature survey. The goal of the article is to underscore the cardinal features of juvenile chronic myelogenous leukemia that are useful for diagnosis, and to highlight recent advances in the understanding of the biology and treatment of the disease.
青少年慢性粒细胞白血病（JCML）是一种影响4岁以下儿童的单核细胞-组织细胞系恶性造血疾病。由于该疾病仅占所有儿童白血病的2%，即使在大型医疗中心，对其的经验也很有限。本综述总结了我们对JCML进行的为期10年的机构研究以及全面的文献调查。本文的目的是强调有助于诊断的青少年慢性粒细胞白血病的主要特征，并突出在该疾病生物学和治疗理解方面的最新进展。
