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Is sex necessary for the proliferation and transmission of Pneumocystis?

作者信息

Hauser Philippe M, Cushion Melanie T

机构信息

Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.

Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

出版信息

PLoS Pathog. 2018 Dec 6;14(12):e1007409. doi: 10.1371/journal.ppat.1007409. eCollection 2018 Dec.

DOI:10.1371/journal.ppat.1007409
PMID:30521646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6283344/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/6283344/1d12d12e3297/ppat.1007409.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/6283344/c739431bae0b/ppat.1007409.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/6283344/1d12d12e3297/ppat.1007409.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/6283344/c739431bae0b/ppat.1007409.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8df9/6283344/1d12d12e3297/ppat.1007409.g002.jpg

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Functional and Expression Analyses of the Genes Suggest Obligate Sexuality through Primary Homothallism within Host Lungs.基因的功能和表达分析表明,通过宿主肺部的初次同型交配,这些基因具有强制性的性别特征。
mBio. 2018 Feb 20;9(1):e02201-17. doi: 10.1128/mBio.02201-17.
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Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation.
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Nat Commun. 2023 Nov 2;14(1):7026. doi: 10.1038/s41467-023-42685-6.
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Front Fungal Biol. 2021 Sep 1;2:740845. doi: 10.3389/ffunb.2021.740845. eCollection 2021.
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mBio. 2022 Aug 30;13(4):e0085922. doi: 10.1128/mbio.00859-22. Epub 2022 Jun 21.
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