星形胶质细胞“协调”突触成熟和可塑性。
Astrocytes "Chordinate" Synapse Maturation and Plasticity.
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences (DIBS), Durham, NC 27710, USA.
出版信息
Neuron. 2018 Dec 5;100(5):1010-1012. doi: 10.1016/j.neuron.2018.11.027.
A key step in excitatory synapse maturation is the switch in AMPA receptor subunit composition to GluA2-containing calcium-impermeable receptors. Now, Blanco-Suarez et al. (2018) demonstrate that astrocyte-secreted chordin-like 1 drives this process, enabling synapse maturation and limiting plasticity.
兴奋性突触成熟的一个关键步骤是 AMPA 受体亚基组成的转变，形成包含 GluA2 的钙通透性降低的受体。现在，Blanco-Suarez 等人（2018 年）证明，星形胶质细胞分泌的 Chordin 样蛋白 1 驱动了这一过程，使突触成熟并限制了其可塑性。
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