School of Bioengineering and Food, Key Laboratory of Fermentation Engineering, (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan 430068, People's Republic of China.
Nanotechnology. 2019 Feb 15;30(7):075101. doi: 10.1088/1361-6528/aaf442. Epub 2018 Nov 27.
Development of a safe, efficient and inexpensive multifunctional nanoplatform using a facile approach for multimodal imaging and therapeutic functions becomes more and more practically relevant but challenging. In this work, we demonstrated a novel nanocomposites (BiS-Gd) for computed tomography (CT)/magnetic resonance (MR) imaging-guided photothermal therapy (PTT) for cancer in vitro. It was achieved by modification of hydrophobic BiS with a smart amphiphilic gadolinium-chelated ligand. The as-prepared nanocomposites composed of low-cost BiS and gadolinium complexes, showed high stability, excellent biocompatibility and good photostability. It was observed that BiS-Gd nanocomposites can efficiently convert the NIR light into heat, and then suppressed the growth of tumor cells under NIR laser irradiation. Apart from serving as an effective photothermal agent, the as-prepared nanomaterials could induce an efficient contrast enhancement for both CT and MR imaging at low concentrations of Bi and Gd, rendering more accurate diagnosis. This work suggests the potential of BiS-Gd nanomaterials as a novel multifunctional nanoplatform for CT/MR imaging-guided PTT for cancer.
开发一种安全、高效、廉价的多功能纳米平台，采用简便的方法实现多模态成像和治疗功能，在实践中变得越来越重要，但也极具挑战性。在这项工作中，我们展示了一种新型的纳米复合材料（BiS-Gd），用于体外计算机断层扫描（CT）/磁共振（MR）成像引导的光热治疗（PTT）癌症。这是通过用智能两亲性钆螯合物修饰疏水性 BiS 来实现的。所制备的纳米复合材料由低成本的 BiS 和钆配合物组成，表现出高稳定性、优异的生物相容性和良好的光稳定性。结果表明，BiS-Gd 纳米复合材料可以有效地将近红外光转化为热量，然后在近红外激光照射下抑制肿瘤细胞的生长。除了作为一种有效的光热剂外，所制备的纳米材料还可以在低浓度的 Bi 和 Gd 下，分别为 CT 和 MR 成像提供有效的对比度增强，从而实现更准确的诊断。这项工作表明，BiS-Gd 纳米材料有望成为一种新型的多功能纳米平台，用于 CT/MR 成像引导的癌症光热治疗。
