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从醉鱼草属植物叶片中得到的一种新的酚糖苷。

A new phenolic glycoside from the Maxim. leaves.

机构信息

a Institute of New Energy and Low-Carbon Technology, Sichuan University , Chengdu , P.R. China.

b National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application , Chengdu , P.R. China.

出版信息

Nat Prod Res. 2019 Oct;33(20):3016-3020. doi: 10.1080/14786419.2018.1511553. Epub 2018 Dec 9.

DOI:10.1080/14786419.2018.1511553
PMID:30526063
Abstract

Phytochemical investigation on the ethyl acetate extract of Maxim. Leaves led to the isolation of four phenolic glycoside isomers (). Compound appeared to be new reported phenolic glycoside, while compound was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds and showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds and showed a significant activity of scavenging the ABTS free radical. Compounds and exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds and . Moreover, compound presented the highest cytotoxicity against MCF cell lines with IC value of 37.17 ± 0.26 μg/mL than compounds , and .

摘要

从八角枫(Maxim.)叶的乙酸乙酯提取物中进行植物化学研究,分离得到四个酚糖苷异构体()。化合物 似乎是一种新报道的酚糖苷,而化合物 则是首次从该种中分离得到。通过 IR、UV、HRESI-MS 以及 1D 和 2D NMR 光谱分析,并与先前报道的数据进行比较,确定了它们的结构。化合物 和 对 DPPH 自由基的清除活性强于其他两种化合物,而化合物 和 对 ABTS 自由基的清除活性较强。化合物 和 对 HepG2 细胞系的细胞毒性强于化合物 和 。此外,化合物 对 MCF 细胞系的细胞毒性最高,IC 值为 37.17 ± 0.26 μg/mL,优于化合物 、 和 。

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