来自地锦草根部的抗氧化苯乙酮糖苷。
Antioxidant acetophenone glycosides from the roots of Euphorbia ebracteolata Hayata.
作者信息
Wang Anhua, Gao Xiaoxv, Huo Xiaokui, Huang Shanshan, Feng Lei, Sun Chengpeng, Zhang Baojing, Ma Xiaochi, Jia Jingming, Wang Chao
机构信息
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
b College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology , Dalian Medical University , Dalian , People's Republic of China.
出版信息
Nat Prod Res. 2018 Sep;32(18):2187-2192. doi: 10.1080/14786419.2017.1371160. Epub 2017 Aug 31.
A new acetophenone diglycoside, 2,4-dihydroxy-6-methoxy-3-methyl-acetophenone 4-O-gentiobioside (1), along with six know analogues (2-6), were isolated from the roots of Euphorbia ebracteolata. The structures of these isolates were determined by UV, HRESIMS, 1D and 2D NMR spectral analyses. In addition, all acetophenones showed moderate DPPH free radical scavenging capability, and no cytotoxicity against five human cancer cell lines.
从地锦草的根中分离得到一种新的苯乙酮二糖苷，2,4-二羟基-6-甲氧基-3-甲基苯乙酮4-O-龙胆二糖苷（1），以及六个已知类似物（2-6）。通过紫外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振光谱分析确定了这些分离物的结构。此外，所有苯乙酮均表现出中等程度的二苯基苦味酰基自由基清除能力，并且对五种人类癌细胞系均无细胞毒性。
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