Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; email:
Annu Rev Physiol. 2019 Feb 10;81:607-627. doi: 10.1146/annurev-physiol-020518-114339. Epub 2018 Dec 10.
Physical inactivity is one of the leading health problems in the world. Strong epidemiological and clinical evidence demonstrates that exercise decreases the risk of more than 35 different disorders and that exercise should be prescribed as medicine for many chronic diseases. The physiology and molecular biology of exercise suggests that exercise activates multiple signaling pathways of major health importance. An anti-inflammatory environment is produced with each bout of exercise, and long-term anti-inflammatory effects are mediated via an effect on abdominal adiposity. There is, however, a need to close the gap between knowledge and practice and assure that basic research is translated, implemented, and anchored in society, leading to change of praxis and political statements. In order to make more people move, we need a true translational perspective on exercise as medicine, from molecular and physiological events to infrastructure and architecture, with direct implications for clinical practice and public health.
身体活动不足是世界范围内主要的健康问题之一。强有力的流行病学和临床证据表明，运动可降低 35 多种不同疾病的风险，而且对于许多慢性疾病，运动应该被开为药物进行治疗。运动的生理学和分子生物学表明，运动激活了多个具有重要健康意义的信号通路。每次运动都会产生抗炎环境，而通过对腹部肥胖的影响则可产生长期的抗炎作用。然而，需要缩小知识和实践之间的差距，并确保基础研究得到转化、实施并扎根于社会，从而导致实践和政治声明的改变。为了让更多的人运动，我们需要从分子和生理事件到基础设施和建筑，对运动作为药物进行真正的转化视角，这对临床实践和公共卫生具有直接影响。
