Center of Investigation of Endocrinology and Nutrition, Medicine School and Dpt of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Center of Investigation of Endocrinology and Nutrition, Medicine School and Dpt of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Clin Nutr. 2019 Dec;38(6):2632-2638. doi: 10.1016/j.clnu.2018.11.013. Epub 2018 Nov 30.
The role of CB2R gene variants on weight loss after a dietary intervention has been investigated in few studies.
We evaluate the effect of this genetic variant (rs3123554) of CB2R gene on cardiovascular risk factors and weight loss secondary to high monounsaturated fat vs a high polyunsaturated fat hypocaloric diets.
A Caucasian population of 362 obese patients was enrolled. Patients were randomly allocated during 3 months to one of two diets (Diet P high polyunsaturated (PUFAs) fat hypocaloric diet vs, Diet M high monounsaturated (MUFAs) fat hypocaloric diet).
In both genotype groups (GG vs GA+AA), body weight, body mass index (BMI), fat mass, waist circumference and systolic blood pressure decreased after diet P and M. Body weight, BMI, fat mass and waist circumference were higher in A allele carriers than non A allele carriers. The improvement of these parameters was higher in non A allele carriers than A allele carriers. In non A allele carriers with both diets, the decrease of total cholesterol, LDL-cholesterol, insulin and HOMA-IR was higher than A allele carriers after both diets. After diet P, triglyceride levels decrease in non A allele carriers.
Our data suggest that carriers of the minor allele of rs3123554 variant of CB2R gene lose less body weight during to different hypocaloric diets with different fatty acid. Moreover, non A-allele carriers showed a better response of LDL-cholesterol, HOMA-IR and insulin levels than A-carriers with both hypocaloric diets.
已有少数研究探讨了 CB2R 基因变异体在饮食干预后体重减轻中的作用。
我们评估了这种 CB2R 基因的遗传变异（rs3123554）对心血管危险因素和高单不饱和脂肪与高多不饱和脂肪低热量饮食引起的体重减轻的影响。
纳入了 362 名肥胖的白种人患者。患者在 3 个月内随机分配到两种饮食之一：饮食 P（高多不饱和脂肪酸（PUFAs）低热量饮食）或饮食 M（高单不饱和脂肪酸（MUFAs）低热量饮食）。
在两种基因型组（GG 与 GA+AA）中，饮食 P 和 M 后体重、体重指数（BMI）、体脂、腰围和收缩压均降低。A 等位基因携带者的体重、BMI、体脂和腰围均高于非 A 等位基因携带者。非 A 等位基因携带者的这些参数改善程度高于 A 等位基因携带者。在两种饮食中非 A 等位基因携带者中，与 A 等位基因携带者相比，两种饮食后总胆固醇、LDL-胆固醇、胰岛素和 HOMA-IR 降低幅度更高。饮食 P 后，非 A 等位基因携带者的甘油三酯水平降低。
我们的数据表明，CB2R 基因 rs3123554 变异的次要等位基因携带者在不同的低热量饮食中体重减轻较少，这些饮食的脂肪酸不同。此外，与 A 等位基因携带者相比，非 A 等位基因携带者在两种低热量饮食中对 LDL-胆固醇、HOMA-IR 和胰岛素水平的反应更好。
