Institute of Hypertension, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Department of Cardiology, Jiangsu Province Hospital of Traditional Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Hypertens Res. 2019 Mar;42(3):385-391. doi: 10.1038/s41440-018-0156-8. Epub 2018 Dec 10.
Emerging evidence supports a causal role for the immunoglobulin-M (IgM) as a protector of atherosclerosis. Since arterial stiffness is an index of subclinical atherosclerosis, we propose that IgM may play an important role in arterial stiffness. As the level of IgM differs between sexes, we investigate the sex-specific association of serum IgM with arterial stiffness in a Chinese population. The study subjects were recruited from Danyang in 2017. Using the Omron VP-1000 system, we measured brachial ankle pulse wave velocity (baPWV). Serum IgM concentration was measured by the immunoturbidimetry method. The 1030 study participants (mean age = 54.3 ± 9.0 years) included 407 men (39.5%), 428 hypertensive (41.6%), 80 diabetic (7.8%), and 512 arterial stiffness patients (49.7%). Serum IgM concentration was lower in men than women (0.97 vs. 1.26 μg/mL, P < 0.001) and negatively with alcohol intake (r = -0.11 in men and r = -0.07 in women, P ≤ 0.09). In multiple regression analyses, serum IgM concentration was negatively associated with baPWV in women (-0.82 m/s per 10-time increase in serum IgM concentration, P = 0.009) but not in men. In multivariable logistic regression analyses, elevated serum IgM concentration was associated with lower risks for arterial stiffness in women (OR = 0.26; 95% CI 0.08-0.82; P = 0.02) but not in men (OR = 0.66; 95% CI 0.17-2.62; P = 0.55). Categorical analyses produced similar results. Serum IgM is negatively associated with baPWV and accordingly associated with a lower risk of arterial stiffness in women.
新出现的证据支持免疫球蛋白-M（IgM）作为动脉粥样硬化保护因子的作用。由于动脉僵硬度是亚临床动脉粥样硬化的指标，我们提出 IgM 可能在动脉僵硬度中起重要作用。由于 IgM 水平在性别之间存在差异，因此我们在中国人群中研究了血清 IgM 与动脉僵硬度的性别特异性关联。研究对象于 2017 年从丹阳招募。使用欧姆龙 VP-1000 系统，我们测量了肱踝脉搏波速度（baPWV）。通过免疫比浊法测量血清 IgM 浓度。1030 名研究参与者（平均年龄 54.3±9.0 岁）包括 407 名男性（39.5%）、428 名高血压患者（41.6%）、80 名糖尿病患者（7.8%）和 512 名动脉僵硬患者（49.7%）。男性血清 IgM 浓度低于女性（0.97 对 1.26μg/ml，P<0.001），与饮酒呈负相关（男性 r=-0.11，女性 r=-0.07，P≤0.09）。在多元回归分析中，血清 IgM 浓度与女性的 baPWV 呈负相关（血清 IgM 浓度每增加 10 倍，baPWV 降低 0.82m/s，P=0.009），但与男性无关。在多变量逻辑回归分析中，高血清 IgM 浓度与女性动脉僵硬风险降低相关（OR=0.26；95%CI 0.08-0.82；P=0.02），但与男性无关（OR=0.66；95%CI 0.17-2.62；P=0.55）。分类分析得出了类似的结果。血清 IgM 与 baPWV 呈负相关，因此与女性动脉僵硬风险降低相关。
