Wit J M, van't Hof M A, Van den Brande J L
Department of Pediatrics, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
Eur J Pediatr. 1988 Aug;147(6):588-92. doi: 10.1007/BF00442469.
Skinfold thickness (ST) was measured in 43 children with various forms of growth hormone (GH) deficiency during the first year of GH therapy. The average (and SEM) initial ST, expressed as standard deviation score (SDS) was 1.17 (0.25) for subscapular, 0.63 (0.18) for triceps, and 0.40 (0.21) for biceps ST. During therapy the average decrease is 1 SD. Children in the pubertal age group and those with partial GH deficiency showed smaller decreases. A larger decrease of triceps ST was associated with lower GH and insulin peaks, and lower age, bone age and initial weight-for-height. Some correlations between ST decrease and growth response in the first year were significant, but still too low to allow of reliable predictions. The same was true for other clinical parameters. These data indicate that a chronic lack of GH leads to unequal fat distribution, possibly due to different sensitivities to GH in the trunk and extremities. The variability of ST responses to GH therapy limits clinical applications.
在生长激素（GH）治疗的第一年，对43名患有各种形式生长激素缺乏症的儿童测量了皮褶厚度（ST）。以标准差评分（SDS）表示的平均（及标准误）初始ST，肩胛下皮褶厚度为1.17（0.25），肱三头肌皮褶厚度为0.63（0.18），肱二头肌皮褶厚度为0.40（0.21）。在治疗期间，平均下降幅度为1个标准差。青春期年龄组的儿童和部分生长激素缺乏的儿童下降幅度较小。肱三头肌皮褶厚度下降幅度较大与生长激素和胰岛素峰值较低以及年龄、骨龄和初始身高体重较低有关。第一年皮褶厚度下降与生长反应之间的一些相关性具有显著性，但仍太低，无法进行可靠预测。其他临床参数也是如此。这些数据表明，长期缺乏生长激素会导致脂肪分布不均，可能是由于躯干和四肢对生长激素的敏感性不同。皮褶厚度对生长激素治疗反应的变异性限制了其临床应用。
