Wit J M, Faber J A, Van den Brande J L
Acta Paediatr Scand. 1986 Sep;75(5):767-73. doi: 10.1111/j.1651-2227.1986.tb10288.x.
The growth response during the first and second years of human growth hormone (hGH) treatment was studied in 14 prepubertal children with so-called "partial" GH deficiency (peak GH between 8 and 15 mU/l) and compared to 28 prepubertal children with "total" GH deficiency (peak GH less than 8 mU/l). There was no difference in growth acceleration between children with partial and total GH deficiency, when initial covariables were taken into account. In a stepwise multiple regression analysis initial stature, pre-treatment growth velocity and skinfold thickness were shown to be most related to growth response, but after exclusion of 3 children with a genetic form of total GH deficiency and partial TSH deficiency this relationship was lost. GH levels during provocation tests and auxological criteria have a poor predictive value for growth response to hGH therapy.
对14名青春前期所谓“部分”生长激素（hGH）缺乏（生长激素峰值在8至15 mU/l之间）的儿童在接受人生长激素治疗的第一年和第二年期间的生长反应进行了研究，并与28名青春前期“完全”生长激素缺乏（生长激素峰值低于8 mU/l）的儿童进行了比较。当考虑初始协变量时，部分和完全生长激素缺乏儿童之间的生长加速没有差异。在逐步多元回归分析中，初始身高、治疗前生长速度和皮褶厚度显示与生长反应最相关，但在排除3名患有遗传性完全生长激素缺乏和部分促甲状腺激素缺乏的儿童后，这种关系消失了。激发试验期间的生长激素水平和人体测量标准对hGH治疗的生长反应预测价值较差。
