Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G
Br Med J (Clin Res Ed). 1984 May 12;288(6428):1401-4. doi: 10.1136/bmj.288.6428.1401.
In a prospective study of risk factors for ischaemic heart disease 792 54 year old men selected by year of birth (1913) and residence in Gothenburg agreed to attend for questioning and a battery of anthropometric and other measurements in 1967. Thirteen years later these baseline findings were reviewed in relation to the numbers of men who had subsequently suffered a stroke, ischaemic heart disease, or death from all causes. Neither quintiles nor deciles of initial indices of obesity (body mass index, sum of three skinfold thickness measurements, waist or hip circumference) showed a significant correlation with any of the three end points studied. Statistically significant associations were, however, found between the waist to hip circumference ratio and the occurrence of stroke (p = 0.002) and ischaemic heart disease (p = 0.04). When the confounding effect of body mass index or the sum of three skinfold thicknesses was accounted for the waist to hip circumference ratio was significantly associated with all three end points. This ratio, however, was not an independent long term predictor of these end points when smoking, systolic blood pressure, and serum cholesterol concentration were taken into account. These results indicate that in middle aged men the distribution of fat deposits may be a better predictor of cardiovascular disease and death than the degree of adiposity.
在一项关于缺血性心脏病危险因素的前瞻性研究中，792名1913年出生且居住在哥德堡的54岁男性同意在1967年接受问卷调查以及一系列人体测量和其他检测。13年后，对这些基线调查结果进行了回顾，将其与随后出现中风、缺血性心脏病或因各种原因死亡的男性人数进行关联分析。肥胖初始指标（体重指数、三项皮褶厚度测量值之和、腰围或臀围）的五分位数或十分位数与所研究的三个终点中的任何一个均未显示出显著相关性。然而，腰臀围比与中风发生率（p = 0.002）和缺血性心脏病发生率（p = 0.04）之间存在统计学上的显著关联。当考虑体重指数或三项皮褶厚度之和的混杂效应时，腰臀围比与所有三个终点均显著相关。然而，当考虑吸烟、收缩压和血清胆固醇浓度时，该比值并非这些终点的独立长期预测指标。这些结果表明，对于中年男性，脂肪沉积的分布可能比肥胖程度更能预测心血管疾病和死亡。
