Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, 060-8648 Japan.
Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, 565-0871 Japan.
Sci Data. 2018 Dec 11;5:180243. doi: 10.1038/sdata.2018.243.
Sepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection. Sepsis can induce the dysregulation of systemic coagulation and fibrinolytic systems, resulting in disseminated intravascular coagulation (DIC), which is associated with a high mortality rate. Although there is no international consensus on available treatments for sepsis-induced DIC, DIC diagnosis and treatment are commonly performed in Japanese clinical settings. Therefore, clinical data related to sepsis-induced DIC diagnosis and treatment can be obtained from Japanese clinical settings. We performed a retrospective nationwide observational study (Japan Septic Disseminated Intravascular Coagulation [J-SEPTIC DIC] study) to collect data regarding characteristics of sepsis patients in Japan, with a focus on coagulofibrinolytic dysregulation and DIC treatment received by each patient. The J-SEPTIC DIC study collected information for a total of 3,195 patients with severe sepsis and septic shock and is the largest data set in Japan on DIC diagnosis and treatment in clinical settings.
脓毒症是一种由感染引起的生理、病理和生化异常的综合征。脓毒症可引起全身凝血和纤维蛋白溶解系统的失调，导致弥散性血管内凝血（DIC），这与高死亡率相关。尽管对于脓毒症引起的 DIC 的可用治疗方法没有国际共识，但 DIC 的诊断和治疗在日本临床环境中通常进行。因此，可以从日本临床环境中获得与脓毒症引起的 DIC 诊断和治疗相关的临床数据。我们进行了一项回顾性全国性观察研究（日本脓毒症弥散性血管内凝血[J-SEPTIC DIC]研究），以收集有关日本脓毒症患者特征的数据，重点是每个患者的凝血纤维蛋白溶解失调和接受的 DIC 治疗。J-SEPTIC DIC 研究共收集了 3195 名严重脓毒症和脓毒性休克患者的信息，是日本关于临床环境中 DIC 诊断和治疗的最大数据集。
