血清孕酮在异位妊娠诊断中的应用：一项有价值的诊断试验？

Serum progesterone in the diagnosis of ectopic pregnancy: a valuable diagnostic test?

作者信息

Buck R H, Joubert S M, Norman R J

机构信息

Department of Chemical Pathology, University of Natal Medical School, Durban, Congella, Republic of South Africa.

出版信息

Fertil Steril. 1988 Nov;50(5):752-5. doi: 10.1016/s0015-0282(16)60310-2.

DOI:10.1016/s0015-0282(16)60310-2

PMID:3053256

Abstract

The value of a single serum progesterone (P) assay in the diagnostic work-up of suspected ectopic pregnancy was investigated in 89 patients with ectopic pregnancy and 27 patients with incomplete abortion. Reference values for P in the blood were obtained from 77 patients with normal intrauterine pregnancies in the first trimester. With the use of a discriminatory level of 63 nmol/l (20 ng/ml), sensitivity of 92%, specificity of 84%, positive predictive index of 90%, and negative predictive index of 87% were achieved. Addition of pelvic ultrasound further improved the diagnostic accuracy. It is concluded that serum P measurement offers a valuable adjunct to existing methods of diagnosis of ectopic pregnancy.

摘要

对89例异位妊娠患者和27例不全流产患者进行了研究，以探讨单次血清孕酮（P）检测在疑似异位妊娠诊断检查中的价值。从77例孕早期宫内妊娠正常的患者中获取了血液中P的参考值。使用63 nmol/l（20 ng/ml）的鉴别水平，灵敏度为92%，特异性为84%，阳性预测指数为90%，阴性预测指数为87%。盆腔超声检查的加入进一步提高了诊断准确性。结论是，血清P检测为现有的异位妊娠诊断方法提供了有价值的辅助手段。