Kitaev E M, Savchenko O N, Slozina N M, Proĭmina F I
Fiziol Zh SSSR Im I M Sechenova. 1988 Jun;74(6):871-7.
The analysis of the maturation of follicular oocytes as well as of the state of gametes after induction of ovulation with PMSG or with GnRH in intact and androgenized rats revealed the dependence of the heterogeneity extent (in morphologic and chromosomal damages) of population of germ cells maturing in vivo and in vitro upon the character of gonadotropin regulation disturbances of folliculogenesis. Stable disorder of reproductive function (androgenization) is followed by a significant increase in number of abnormal gametes under its hormonal correction.
对完整大鼠和雄激素化大鼠用孕马血清促性腺激素(PMSG)或促性腺激素释放激素(GnRH)诱导排卵后,卵泡卵母细胞的成熟情况以及配子状态进行分析,结果显示,体内和体外成熟的生殖细胞群体的异质性程度(形态学和染色体损伤方面)取决于卵泡发生的促性腺激素调节紊乱的特征。生殖功能的稳定紊乱(雄激素化)之后,在激素校正的情况下,异常配子的数量会显著增加。