卡铂诱导的库尼综合征。
Carboplatin-induced Kounis syndrome.
作者信息
Baroni Matteo, Todd Sarah, Pattarino Francesco, Doni Flavio
机构信息
Cardiology Department, Policlinico San Pietro, Via Forlanini 15, 24036 Ponte S. Pietro (BERGAMO), Italy.
出版信息
J Cardiol Cases. 2011 May 6;4(1):e58-e61. doi: 10.1016/j.jccase.2011.04.004. eCollection 2011 Aug.
Abstract
A 50-year-old man in chemotherapy for an advanced lung adenocarcinoma presented with chest pain and cutaneous rash during carboplatin infusion with electrocardiographic (ECG) evidence of an inferior lesion wave. The administration of steroids and nitrates promptly resulted in clinical and ECG normalization, without enzymatic dismission. This reaction was considered compatible with allergic coronary vasospasm (also known as Kounis syndrome), a rare but possible complication of chemotherapy. In these cases prompt diagnosis and a correct approach can avoid useless invasive interventions.
摘要
一名50岁晚期肺腺癌男性患者在接受卡铂化疗期间，输注卡铂时出现胸痛和皮疹，心电图显示下壁导联异常。给予类固醇和硝酸盐后，临床症状和心电图迅速恢复正常，酶学指标未出现异常。这种反应被认为与过敏性冠状动脉痉挛（也称为库尼斯综合征）相符，这是化疗罕见但可能出现的并发症。在这些病例中，及时诊断和正确处理可避免不必要的侵入性干预。
相似文献
1
Carboplatin-induced Kounis syndrome.卡铂诱导的库尼综合征。
J Cardiol Cases. 2011 May 6;4(1):e58-e61. doi: 10.1016/j.jccase.2011.04.004. eCollection 2011 Aug.
2
A case of Kounis syndrome associated with transcatheter arterial chemoembolization for hepatocellular carcinoma.一例与经导管动脉化疗栓塞治疗肝细胞癌相关的库尼斯综合征病例。
J Cardiol Cases. 2015 Jun 12;12(4):106-109. doi: 10.1016/j.jccase.2015.05.007. eCollection 2015 Oct.
3
Vancomycin-induced Kounis Syndrome.万古霉素诱导的 Kounis 综合征。
Am J Emerg Med. 2019 Sep;37(9):1806.e3-1806.e5. doi: 10.1016/j.ajem.2019.06.004. Epub 2019 Jun 3.
4
Kounis Syndrome: A Case of Vancomycin-Associated Coronary Artery Vasospasm Resulting in Myocardial Infarction.库尼斯综合征：一例由万古霉素相关冠状动脉痉挛导致心肌梗死的病例。
CJC Open. 2021 Nov 17;4(3):337-339. doi: 10.1016/j.cjco.2021.11.003. eCollection 2022 Mar.
5
A Curious Case of Coronary Vasospasm with Cardiogenic Shock: Type 1 Kounis Syndrome Complicated by Eosinophilic Myocarditis.一例伴有心源性休克的冠状动脉痉挛罕见病例：1型库尼斯综合征合并嗜酸性粒细胞性心肌炎
Cureus. 2019 Apr 22;11(4):e4522. doi: 10.7759/cureus.4522.
6
Type I Kounis syndrome variant: A case report and literature review.I型库尼斯综合征变体：一例病例报告及文献综述。
Avicenna J Med. 2018 Jan-Mar;8(1):37-39. doi: 10.4103/ajm.AJM_114_17.
7
Acute coronary syndrome secondary to allergic coronary vasospasm (Kounis Syndrome): a case series, follow-up and literature review.过敏性冠状动脉痉挛继发急性冠状动脉综合征（库尼斯综合征）：病例系列、随访及文献综述
BMC Cardiovasc Disord. 2018 Feb 27;18(1):42. doi: 10.1186/s12872-018-0781-9.
8
[Coronary vasospasm in a child allergic to latex: Kounis syndrome].[一名对乳胶过敏儿童的冠状动脉痉挛：库尼斯综合征]
Arch Argent Pediatr. 2019 Oct 1;117(5):e514-e518. doi: 10.5546/aap.2019.e514.
9
Kounis syndrome: a stinging case of ST-elevation myocardial infarction.库尼斯综合征：一例伴有刺痛症状的ST段抬高型心肌梗死
Heart Lung Circ. 2015 Apr;24(4):e48-50. doi: 10.1016/j.hlc.2014.11.026. Epub 2014 Dec 16.
10
Vancomycin-induced coronary artery spasm: a case of Kounis syndrome.万古霉素诱发的冠状动脉痉挛：一例库尼综合征病例
BMJ Case Rep. 2018 Jan 17;2018:bcr-2017-222846. doi: 10.1136/bcr-2017-222846.
引用本文的文献
1
Paclitaxel-related type I Kounis Syndrome in a very young patient with HER2-positive breast cancer and the role of genomics to disentangle a complex therapeutic scenario: a case report and narrative review.一名非常年轻的HER2阳性乳腺癌患者发生的紫杉醇相关I型库尼斯综合征以及基因组学在解析复杂治疗情况中的作用：病例报告与叙述性综述
Breast. 2025 Jun;81:104465. doi: 10.1016/j.breast.2025.104465. Epub 2025 Apr 4.
2
Kounis Syndrome: Review of Clinical Cases.Kounis 综合征：临床病例回顾。
Cardiovasc Hematol Disord Drug Targets. 2024;24(2):83-97. doi: 10.2174/011871529X305833240708051508.
3
Cardio-Oncoimmunology: Cardiac Toxicity, Cardiovascular Hypersensitivity, and Kounis Syndrome.心脏肿瘤免疫学：心脏毒性、心血管超敏反应与库尼斯综合征。
Life (Basel). 2024 Mar 18;14(3):400. doi: 10.3390/life14030400.
4
Case Report: Phloroglucinol-Induced Kounis Syndrome.病例报告：间苯三酚诱发的库尼氏综合征。
Front Cardiovasc Med. 2021 May 3;8:668318. doi: 10.3389/fcvm.2021.668318. eCollection 2021.
5
Epirubicin-induced Kounis syndrome.表阿霉素致 Kounis 综合征。
BMC Cardiovasc Disord. 2021 Mar 12;21(1):133. doi: 10.1186/s12872-021-01936-4.
6
Kounis Syndrome Induced by Anisodamine: A Case Report.山莨菪碱诱发的库尼综合征：一例报告
Int J Gen Med. 2020 Dec 14;13:1523-1527. doi: 10.2147/IJGM.S289015. eCollection 2020.
本文引用的文献
1
The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, reexposure, and desensitization.疑似细胞毒药物过敏副作用的复杂临床特征：症状、发病机制、再暴露和脱敏。
Med Clin North Am. 2010 Jul;94(4):835-52, xiii. doi: 10.1016/j.mcna.2010.03.002.
2
Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm?库尼斯综合征（过敏性心绞痛和过敏性心肌梗死）：一种自然范例？
Int J Cardiol. 2006 Jun 7;110(1):7-14. doi: 10.1016/j.ijcard.2005.08.007. Epub 2005 Oct 24.
3
Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management.癌症治疗的心血管并发症：诊断、发病机制与管理
Circulation. 2004 Jun 29;109(25):3122-31. doi: 10.1161/01.CIR.0000133187.74800.B9.
4
Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.以冠状动脉痉挛为表现的卡铂超敏反应——一例报告
Cancer Chemother Pharmacol. 2002 Nov;50(5):429-31. doi: 10.1007/s00280-002-0518-3. Epub 2002 Sep 27.
5
Allergic angina and allergic myocardial infarction: a new twist on an old syndrome.过敏性心绞痛和过敏性心肌梗死：一种旧综合征的新情况。
Can J Cardiol. 2002 May;18(5):508-11.
6
Vasospastic angina after chemotherapy by with carboplatin and etoposide in a patient with lung cancer.一名肺癌患者在接受卡铂和依托泊苷化疗后发生变异性心绞痛。
Jpn Circ J. 1996 Mar;60(3):185-8. doi: 10.1253/jcj.60.185.
7
Histamine-induced coronary artery spasm: the concept of allergic angina.组胺诱导的冠状动脉痉挛：过敏性心绞痛的概念。
Br J Clin Pract. 1991 Summer;45(2):121-8.
Zotero 插件