一名患有急性早幼粒细胞白血病的孕妇发生心肌心包炎。
Myopericarditis in a pregnant woman with acute promyelocytic leukemia.
作者信息
Oehler Andrew, Shah Shimoli
机构信息
OHSU Internal Medicine, Portland, OR, USA.
OHSU Knight Cardiovascular Institute, Portland, OR, USA.
出版信息
J Cardiol Cases. 2014 Aug 19;10(5):200-203. doi: 10.1016/j.jccase.2014.07.010. eCollection 2014 Nov.
Abstract
Acute promyelocytic leukemia (APL) is a form of acute leukemia with a characteristic translocation, t(15;17), and is considered a hematologic emergency, typically treated with all-trans retinoic acid and an anthracycline. We present the case of a young, gravid woman who was diagnosed with APL in the third trimester, initiated typical treatment, and suffered uncommon cardiac complications. < Myopericarditis is not a side effect often encountered in the management of acute promyelocytic leukemia with alpha t-retinoic acid, and its mechanism is incompletely understood but possibly related to the differentiation syndrome. This complication can be effectively treated with systemic glucocorticoids, supportive care, and withdrawal of the offending agent, even in the pregnant population.>.
摘要
急性早幼粒细胞白血病（APL）是一种急性白血病，具有特征性易位t(15;17)，被视为血液学急症，通常采用全反式维甲酸和蒽环类药物治疗。我们报告了一例年轻的孕妇病例，她在孕晚期被诊断为APL，开始接受典型治疗，并出现了罕见的心脏并发症。<心肌心包炎并非全反式维甲酸治疗急性早幼粒细胞白血病时常见的副作用，其机制尚未完全明确，但可能与分化综合征有关。即使在孕妇人群中，这种并发症也可通过全身糖皮质激素、支持治疗以及停用致病药物得到有效治疗。>
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