State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Nat Prod Rep. 2019 May 22;36(5):788-809. doi: 10.1039/c8np00041g.
Covering: 2000 to 2018 (October) Trillions of microbes, collectively termed as gut microbiota, reside in the gastrointestinal tract and are involved in the physiology of their hosts. In humans, disease incidence and medical therapy are found to be associated with gut microbiota composition. Since ethnomedicines are largely plant-derived and orally ingested, this review summarizes the interactions of gut microbiota with ethnomedicine constituents (overwhelmingly, natural phytochemicals) to highlight the knowledge accumulation in (1) the modulation of the gut microbiota profile by ingested natural compounds, and (2) the gut microbial conversion of natural products into the 'daughter molecules' with potent bioactivities. By understanding such complex interactions of gut microbiota with ethnomedicines and/or the phytochemicals thereof, a fascinating frontier of natural-product chemistry may be substantially activated to conceptualize future therapeutic strategies.
2000 年至 2018 年（10 月）。数以万亿计的微生物，统称为肠道微生物群，存在于胃肠道中，并参与宿主的生理机能。在人类中，疾病的发病率和医疗疗法与肠道微生物群的组成有关。由于民族药物主要来源于植物并经口服摄入，因此本综述总结了肠道微生物群与民族药物成分（绝大多数为天然植物化学物质）的相互作用，以强调以下两方面知识的积累：（1）摄入的天然化合物对肠道微生物群谱的调节，以及（2）肠道微生物将天然产物转化为具有强大生物活性的“衍生分子”。通过了解肠道微生物群与民族药物和/或其植物化学物质之间的这种复杂相互作用，可以极大地激活天然产物化学的一个迷人前沿领域，以构想未来的治疗策略。
