Frosch P J, Ruder H, Stiefel A, Mehls O, Bersch A
Universitäts-Hautklinik Heidelberg.
Hautarzt. 1988 Sep;39(9):611-6.
After 3 months of immunosuppressive treatment with cyclosporin because of a focal segmental glomerulosclerosis, a 13-year-old female developed marked gingival hyperplasia, hypertrichosis of the arms and papulo-vesicular skin lesions on the left leg. Histological and immunohistological examinations of the gingivae showed hyperplasia of the mucosa with perivascular infiltrates of plasma and B cells in the submucosa. The lesions on the leg revealed signs of cutaneous vascular inflammation with eosinophils, but there was no evidence of leucocytoclastic vasculitis. Ten months after discontinuation of cyclosporin, the lesions had nearly regressed. The patient's renal function deteriorated progressively to the point of terminal insufficiency.
一名13岁女性因局灶节段性肾小球硬化接受了3个月的环孢素免疫抑制治疗，之后出现了明显的牙龈增生、手臂多毛症以及左腿的丘疹水疱性皮肤病变。牙龈的组织学和免疫组织学检查显示黏膜增生，黏膜下层有浆细胞和B细胞的血管周围浸润。腿部病变显示有嗜酸性粒细胞的皮肤血管炎症迹象，但没有白细胞破碎性血管炎的证据。停用环孢素10个月后，病变几乎消退。患者的肾功能逐渐恶化至终末期肾功能不全。
