Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA.
Department of Neuroscience, Stony Brook University, Stony Brook, NY, USA.
Mol Imaging Biol. 2019 Oct;21(5):926-934. doi: 10.1007/s11307-018-1300-1.
To determine if one venous blood sample can substitute full arterial sampling in quantitative modeling for multiple positron emission tomography (PET) radiotracers using simultaneous estimation of the input function (SIME).
Participants underwent PET imaging with [C]ABP688, [C]CUMI-101, and [C]DASB. Full arterial sampling and additional venous blood draws were performed for quantification with the arterial input function (AIF) and SIME using one arterial or venous (vSIME) sample.
Venous and arterial metabolite-corrected plasma activities were within 6 % of each other at varying time points. vSIME- and AIF-derived outcome measures were in good agreement, with optimal sampling times of 12 min ([C]ABP688), 90 min ([C]CUMI-101), and 100 min ([C]DASB). Simulation-based power analyses revealed that SIME required fewer subjects than the AIF method to achieve statistical power, with significant reductions for [C]CUMI-101 and [C]DASB with vSIME. Replication of previous findings and test-retest analyses bolstered the simulation analyses.
We demonstrate the feasibility of AIF recovery using SIME with one venous sample for [C]ABP688, [C]CUMI-101, and [C]DASB. This method simplifies PET acquisition while allowing for fully quantitative modeling, although some variability and bias are present with respect to AIF-based quantification, which may depend on the accuracy of the single venous blood measurement.
使用同时估计输入函数（SIME），确定在使用多个正电子发射断层扫描（PET）放射性示踪剂进行定量建模时，是否可以用一个静脉血样代替全动脉采样。
参与者接受 [C]ABP688、[C]CUMI-101 和 [C]DASB 的 PET 成像。为了使用动脉或静脉（vSIME）样本进行定量，同时进行全动脉采样和额外的静脉采血，以获得动脉输入函数（AIF）和 SIME。
在不同的时间点，静脉和动脉代谢校正后血浆活性相差在 6%以内。vSIME 和 AIF 衍生的结果测量值之间具有良好的一致性，最佳采样时间为 12 分钟（[C]ABP688）、90 分钟（[C]CUMI-101）和 100 分钟（[C]DASB）。基于模拟的功效分析表明，SIME 比 AIF 方法需要更少的受试者来达到统计功效，对于 [C]CUMI-101 和 [C]DASB，vSIME 的减少效果显著。对先前发现的复制和测试-重测分析支持了模拟分析。
我们证明了使用 SIME 从单个静脉样本中恢复 AIF 对于 [C]ABP688、[C]CUMI-101 和 [C]DASB 的可行性。这种方法简化了 PET 采集，同时允许进行完全定量建模，尽管与基于 AIF 的定量相比存在一些变异性和偏差，这可能取决于单个静脉血测量的准确性。
