Kraeuter Ann-Katrin, Guest Paul C, Sarnyai Zoltán
Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.
Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.
Methods Mol Biol. 2019;1916:75-80. doi: 10.1007/978-1-4939-8994-2_5.
The forced swim test assesses learned helplessness, which is a feature of depression-like behavior in rodents. This test has also been used in testing the efficacy of existing and novel antidepressant drugs. It is based on the natural tendency of rodents to escape from water. Rodents are placed in a cylinder filled with water and the presumption is that those with a depression-like phenotype give up swimming earlier than those that are not depressed. Furthermore, antidepressant drugs reverse this effect. This chapter describes the basic setup and conduction of the test, along with interpretation of the results. It should be emphasized that this test should be conducted as part of a series of behavioral assessments in order to increase the accuracy of the results.
强迫游泳试验用于评估习得性无助，这是啮齿动物抑郁样行为的一个特征。该试验也已被用于测试现有和新型抗抑郁药物的疗效。它基于啮齿动物从水中逃脱的自然倾向。将啮齿动物置于装满水的圆筒中，假定具有抑郁样表型的动物比未抑郁的动物更早放弃游泳。此外，抗抑郁药物可逆转这种效应。本章描述了该试验的基本设置和实施方法，以及结果解读。应当强调的是，该试验应作为一系列行为评估的一部分进行，以提高结果的准确性。
