苯并环丁酮稠合螺环吲哚的合成：亚胺叶立德和芳基亚苄基苯并环丁酮的 1,3-偶极环加成反应。
Synthesis of benzosuberone-tethered spirooxindoles: 1-3-dipolar cycloaddition of azomethine ylides and arylidene benzosuberones.
机构信息
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, 625021, India.
X-ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College Station, USA.
出版信息
Mol Divers. 2019 Aug;23(3):669-680. doi: 10.1007/s11030-018-9901-9. Epub 2018 Dec 10.
PMID:30535898
Abstract
Expedient synthesis of benzosuberone-tethered spirooxindoles was accomplished by a three-component 1,3-dipolar cycloaddition reaction between azomethine ylide (generated in situ) and arylidene benzosuberone. This protocol offers good yield and wide functional group tolerance under mild reaction condition with high regio- and stereoselectivities.
摘要
通过亚胺叶立德（原位生成）与苯并环丁酮亚芳基的三组分 1,3-偶极环加成反应，简便地合成了苯并环丁酮连接的螺氧化吲哚。该方法在温和的反应条件下具有高产率、宽官能团容忍度和高区域及立体选择性。
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