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[前庭神经鞘瘤的管理]

[Management of vestibular schwannomas].

作者信息

Schulz Cordelia, Eßer Dirk, Rosahl Steffen, Baljić Izet, Kösling Sabrina, Plontke Stefan K

出版信息

Laryngorhinootologie. 2018 Dec;97(12):875-896. doi: 10.1055/a-0652-7096. Epub 2018 Dec 10.

Abstract

Vestibular schwannomas are benign neoplasms originating from the Schwann cells of the vestibular vestibular nerve of the vestibulocochlear nerve, and rarely from the pars cochlearis. These are tumors that are in contact with the nerve but do not bind the fibers. Benign neoplasms of the Schwann cells of the auditory and equilibrium nerves can also occur primarily in the inner ear and are referred to as intralabyrinthine schwannomas (ILS). Vestibular schwannomas represent 6-7 % of all intracranial and 90 % of cerebellopontine angle tumors. Bilateral occurrence occurs in < 5 % of cases, and then corresponds to type 2 neurofibromatosis. The first symptom is often a unilateral hearing loss. It may then lead to balance disorders, tinnitus, facial paralysis and other impairments. Diagnosis is audiological, vestibular and imaging. Magnetic resonance imaging currently represents the gold standard. Management chooses between an observational strategy and surgery, depending on tumor size, age, and other factors. The possible access routes offer different advantages and disadvantages; the potential complications include the liquorrhoea. Radiation therapy is possible in special cases, and drug therapies are also being tested. In the rehabilitation of the hearing function, in addition to a CROS or BICROS restoration, the cochlear implant has been used with good success. The impact on quality of life is largely determined by hearing impairment, balance disorders, tinnitus, and possibly headache, which must be considered in patient consultation and long-term care.

摘要

前庭神经鞘瘤是起源于前庭蜗神经前庭神经的施万细胞的良性肿瘤,很少起源于蜗部。这些肿瘤与神经接触但不粘连神经纤维。听觉和平衡神经的施万细胞良性肿瘤也可原发于内耳,称为迷路内神经鞘瘤(ILS)。前庭神经鞘瘤占所有颅内肿瘤的6 - 7%,占桥小脑角肿瘤的90%。双侧发病在<5%的病例中出现,此时对应2型神经纤维瘤病。首发症状通常是单侧听力丧失。随后可能导致平衡障碍、耳鸣、面瘫及其他损害。诊断依靠听力学、前庭功能检查及影像学检查。磁共振成像目前是金标准。治疗根据肿瘤大小、年龄和其他因素,在观察策略和手术之间选择。可能的手术入路各有优缺点;潜在并发症包括脑脊液漏。特殊情况下可行放射治疗,药物治疗也在试验中。在听力功能康复方面,除了使用CROS或BICROS助听设备外,人工耳蜗植入也取得了良好效果。对生活质量的影响很大程度上取决于听力损害、平衡障碍、耳鸣,可能还有头痛,在患者咨询和长期护理中必须予以考虑。

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