• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The Evolution of PharmVar.

作者信息

Gaedigk Andrea, Sangkuhl Katrin, Whirl-Carrillo Michelle, Twist Greyson P, Klein Teri E, Miller Neil A

机构信息

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.

School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.

出版信息

Clin Pharmacol Ther. 2019 Jan;105(1):29-32. doi: 10.1002/cpt.1275. Epub 2018 Dec 7.

DOI:10.1002/cpt.1275
PMID:30536702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6312487/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b51/6519007/fb8d1bc3dfc2/CPT-105-29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b51/6519007/fb8d1bc3dfc2/CPT-105-29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b51/6519007/fb8d1bc3dfc2/CPT-105-29-g001.jpg

相似文献

1
The Evolution of PharmVar.药物变异体（PharmVar）的演变
Clin Pharmacol Ther. 2019 Jan;105(1):29-32. doi: 10.1002/cpt.1275. Epub 2018 Dec 7.
2
The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.药物基因变异（PharmVar）联盟：纳入人类细胞色素 P450（CYP）等位基因命名数据库。
Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.
3
Pharmacoepigenetics: its role in interindividual differences in drug response.药物表观遗传学：其在药物反应个体差异中的作用。
Clin Pharmacol Ther. 2009 Apr;85(4):426-30. doi: 10.1038/clpt.2009.2. Epub 2009 Feb 25.
4
Pharmacogenetics-based new therapeutic concepts.基于药物遗传学的新治疗理念。
Drug Metab Rev. 2004 Oct;36(3-4):617-38. doi: 10.1081/dmr-200033458.
5
Variability in response to medicines in older people: phenotypic and genotypic factors.老年人对药物反应的变异性：表型和基因型因素。
Clin Pharmacol Ther. 2009 Apr;85(4):431-3. doi: 10.1038/clpt.2009.1. Epub 2009 Feb 18.
6
Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.CYP3A4活性变异性的遗传成分评估：一种重复给药方法。
Pharmacogenetics. 2000 Jul;10(5):373-88. doi: 10.1097/00008571-200007000-00001.
7
Identifying genetic components of drug response in mice.识别小鼠药物反应的遗传成分。
Pharmacogenomics. 2008 Sep;9(9):1323-30. doi: 10.2217/14622416.9.9.1323.
8
Pharmacogenetics of pharmacoecology: which route to personalized medicine?药物生态学的药物遗传学：通往个性化医疗的哪条途径？
Clin Pharmacol Ther. 2009 Apr;85(4):343-8. doi: 10.1038/clpt.2009.17.
9
Opportunities and obstacles in genotypic prediction of cytochrome P450 phenotypes.细胞色素P450表型的基因型预测中的机遇与障碍
Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):659-661. doi: 10.1080/17425255.2018.1484451. Epub 2018 Jun 14.
10
Nomenclature of the rat Cyp genes and the problems of gene nomenclature in general [Nelson, D.R. (2005), 'Gene nomenclature by default, or BLASTing to Babel', Hum. Genomics Vol. 2, pp. 196-201].大鼠Cyp基因的命名及一般基因命名问题 [纳尔逊，D.R.（2005年），《默认的基因命名，或向巴别塔的BLAST搜索》，《人类基因组学》第2卷，第196 - 201页]
Hum Genomics. 2006 Jun;2(6):343; author reply 343-4. doi: 10.1186/1479-7364-2-6-343.

引用本文的文献

1
New Resources to Identify Characterized DNA Reference Materials for Pharmacogenetic (PGx) and Human Leukocyte Antigen (HLA) Testing: The Genetic Testing Reference Material (GeT-RM) Program PGx Search Tool and GeT-RM Consolidated PGx and HLA Table.用于识别药物遗传学（PGx）和人类白细胞抗原（HLA）检测的特征性DNA参考物质的新资源：基因检测参考物质（GeT-RM）计划PGx搜索工具和GeT-RM综合PGx与HLA表格。
J Mol Diagn. 2025 Jun;27(6):457-464. doi: 10.1016/j.jmoldx.2025.02.008. Epub 2025 Mar 21.
2
PharmVar GeneFocus: CYP2A6.PharmVar 基因焦点：CYP2A6。
Clin Pharmacol Ther. 2024 Oct;116(4):948-962. doi: 10.1002/cpt.3387. Epub 2024 Jul 25.
3

本文引用的文献

1
Pharmacogene Variation Consortium Gene Introduction: NUDT15.药物基因变异联盟基因介绍：NUDT15
Clin Pharmacol Ther. 2019 May;105(5):1091-1094. doi: 10.1002/cpt.1268. Epub 2018 Dec 4.
2
Accurately genotyping CYP2D6: not for the faint of heart.准确对细胞色素P450 2D6进行基因分型：并非胆小者可为。
Pharmacogenomics. 2018 Aug 1;19(13):999-1002. doi: 10.2217/pgs-2018-0105. Epub 2018 Jul 18.
3
Stargazer: a software tool for calling star alleles from next-generation sequencing data using CYP2D6 as a model.Stargazer：一款软件工具，用于从下一代测序数据中调用星型等位基因，以 CYP2D6 作为模型。
Characterization of Reference Materials for CYP3A4 and CYP3A5: A (GeT-RM) Collaborative Project.
用于 CYP3A4 和 CYP3A5 鉴定的参考物质：一个（GeT-RM）合作项目。
J Mol Diagn. 2023 Sep;25(9):655-664. doi: 10.1016/j.jmoldx.2023.06.005. Epub 2023 Jun 23.
4
Practice of CYP450 genotyping and phenotyping in children in a real-life setting.在实际临床环境中对儿童进行CYP450基因分型和表型分析的实践。
Front Pharmacol. 2023 Feb 27;14:1130100. doi: 10.3389/fphar.2023.1130100. eCollection 2023.
5
The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan.巴基斯坦13个民族中维生素K环氧化物还原酶复合体亚基1基因（rs9923231）、细胞色素P450 2C9基因（rs1799853）和细胞色素P450 3A5基因（rs776746）的药物遗传学变异患病率。
Mol Biol Rep. 2023 May;50(5):4017-4027. doi: 10.1007/s11033-023-08304-9. Epub 2023 Feb 27.
6
Long-read HiFi sequencing of NUDT15: Phased full-gene haplotyping and pharmacogenomic allele discovery.NUDT15 的长读 HiFi 测序：分相全基因单体型分析和药物基因组学等位基因发现。
Hum Mutat. 2022 Nov;43(11):1557-1566. doi: 10.1002/humu.24457. Epub 2022 Sep 12.
7
Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone.基于生理的药代动力学建模以描述帕罗西汀、托莫西汀和利培酮的CYP2D6活性评分依赖性代谢。
Pharmaceutics. 2022 Aug 18;14(8):1734. doi: 10.3390/pharmaceutics14081734.
8
Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project.用于 TPMT 和 NUDT15 的参考物质的特征描述：一个 GeT-RM 合作项目。
J Mol Diagn. 2022 Oct;24(10):1079-1088. doi: 10.1016/j.jmoldx.2022.06.008. Epub 2022 Aug 2.
9
Effects of Pharmacokinetic Gene Variation on Therapeutic Drug Levels and Antidepressant Treatment Response.药物代谢基因变异对治疗药物水平和抗抑郁治疗反应的影响。
Pharmacopsychiatry. 2022 Sep;55(5):246-254. doi: 10.1055/a-1872-0613. Epub 2022 Jul 15.
10
Genomewide Association Study of Simvastatin Pharmacokinetics.辛伐他汀药代动力学的全基因组关联研究。
Clin Pharmacol Ther. 2022 Sep;112(3):676-686. doi: 10.1002/cpt.2674. Epub 2022 Jun 24.
Genet Med. 2019 Feb;21(2):361-372. doi: 10.1038/s41436-018-0054-0. Epub 2018 Jun 6.
4
Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, , from whole-genome sequences.星座：一种用于从全基因组序列中对高度多态性药物基因进行快速、自动表型分配的工具。
NPJ Genom Med. 2016 Jan 13;1:15007. doi: 10.1038/npjgenmed.2015.7. eCollection 2016.
5
The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.药物基因变异（PharmVar）联盟：纳入人类细胞色素 P450（CYP）等位基因命名数据库。
Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.